In a nutshell This study examined if adding biological therapy rituximab (Rituxan) to chemotherapy improved treatment results for children with non-Hodgkin lymphoma. The results showed that rituximab improved patients’ chances of survival but also caused more side effects. Some background Treatment results for children with NHL have...
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In a nutshell This study aimed to compare the effectiveness and safety of generic and branded imatinib in patients with newly diagnosed chronic-phase chronic myeloid leukemia. This study concluded that generic and branded imatinib had similar effectiveness and safety in these patients. Some...
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In a nutshell This study aimed to evaluate whether single incision sling (SIS) was as effective and safe as transobturator sling (TOS) for the treatment of stress urinary incontinence in women. The main finding was that SIS was as safe and effective as the TOS. Some background Stress urinary incontinence (SUI) is the involuntary leakage of urine due...
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In a nutshell This study investigated the effectiveness and safety of safinamide (Xadago) in patients with Parkinson's disease (PD) and wearing-OFF symptoms. Researchers suggested that safinamide improved OFF symptoms in these patients. Some background PD is a chronic disease that affects the brain. Over time, brain cells lose their abilities to...
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In a nutshell This study examined if the addition of pembrolizumab (Keytruda) to chemotherapy with pemetrexed (Alimta) and platinum improved treatment results long-term for patients with advanced non-small-cell lung cancer (NSCLC). The authors found that patients who received pembrolizumab with chemotherapy had improved survival and...
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In a nutshell This study examined if subcutaneous (sc) injections of daratumumab (Darzalex) were as effective and safe as intravenous (iv) infusions for patients with relapsed or refractory multiple myeloma (MM). The authors found that sc injections were as effective as iv infusions and caused fewer side effects. Some background Daratumumab...
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In a nutshell This study examined if radiotherapy (RT) would benefit patients with advanced Hodgkin lymphoma (HL) with small tumors following chemotherapy. The authors found that RT may increase patients’ survival without worsening of HL, although this may also increase side effects. Some background Treatment options for patients with...
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In a nutshell This study reviewed the effects of medication, psychological therapy (PT), and non-invasive brain stimulation in depression after stroke. Researchers suggested that medication and PT reduce depression and improve mood in stroke survivors. Some background A stroke happens when the blood flow to the brain is cut-off. This can be a result...
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In a nutshell The study looked at the sequence of dose-escalated radiotherapy (RT) and androgen-deprivation therapy (ADT) in the treatment of local prostate cancer (LPCa). The study found that treatment with ADT before RT had the same outcome as treatment with ADT and RT at the same time. Some background LPCa is a form of cancer that is...
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In a nutshell The study evaluated the addition of pembrolizumab (Keytruda) to etoposide (Etopophos) and platinum chemotherapy drugs for patients with untreated extensive-stage (ES) small-cell lung cancer (SCLC). The study found that pembrolizumab improved progression-free survival (PFS; survival without cancer getting worse) when added to...
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In a nutshell The report recommends how to manage patients with chronic-phase chronic myeloid leukemia (CP-CML) who failed to respond to 2nd generation tyrosine kinase inhibitors (TKIs). The authors suggested to consider patient-specific factors and personalize treatment for such patients. Some background TKIs deactivate cancerous enzymes which cause...
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In a nutshell This study compared the effectiveness of CAR-T treatment for patients with diffuse large B cell lymphoma (DLBCL). The authors found that while a significant number of all patients benefitted from the treatment, some patients were more likely to benefit from it than others. Some background During initial treatment for DLBCL,...
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