In a nutshell This study aimed to investigate the heart function of acute lymphoblastic leukemia survivors who had been treated with anthracyclines. This study concluded that these patients had decreased heart function long after treatment. Some background Anthracyclines are a type of chemotherapy drug. Examples are daunorubicin...
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In a nutshell This study looked at using both chemotherapy and blinatumomab (Blincyto) prior to stem cell transplant (SCT) for patients with relapsed or unresponsive aggressive non-Hodgkin lymphoma (NHL). It found that blinatumomab is an effective second salvage for patients who did not fully respond to chemotherapy. Some background NHL is a...
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In a nutshell This study investigated the benefits and harms of Cerebrolysin in the treatment of stroke. Researchers suggested that Cerebrolysin has a limited effect on preventing death in stroke. Some background Every year, more than 795,000 people in the US have a stroke. A stroke happens when blood flow to the brain is blocked due to a blood clot...
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In a nutshell This study investigated the long-term side effects of low anterior surgery for rectal cancer. Researchers suggested that radiation before surgery is associated with poorer bowel function after surgery. Some background Rectal cancer is a frequent and serious disease. In the US there are 43,340 new cases of rectal cancer every...
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In a nutshell This study investigated the short-term effectiveness and safety of desmopressin in elderly patients with nocturia (NOC; waking up at night more than one time to urinate). Researchers suggested that this drug might be a good and safe option for the treatment of these patients. Some background NOC can be caused by a variety of factors....
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In a nutshell This study was carried out to determine whether combination therapy with a standard-dose pembrolizumab (Keytruda) plus reduced-dose ipilimumab (Yervoy) could be used as a treatment option in patients with advanced melanoma. The study found that this combination had good outcomes and manageable side effects in...
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In a nutshell This study investigated mild ovarian stimulation (OS) for in vitro fertilization (IVF) in women with poor response. They found that there was no difference in outcomes between conventional and mild OS in these women. Some background Controlled ovarian stimulation (COS) is an assisted reproductive technique (ART). It is...
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In a nutshell This study investigated the use of low dose (LD) glucocorticoids (GC) combined with methotrexate (MTX; Otrexup) and hydroxychloroquine (HCQ; Plaquenil).in early rheumatoid arthritis (RA). They found that LD-GCs improved disease activity (DA) combined with MTX and HCQ in these patients. Some background...
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In a nutshell This study investigated the long-term effectiveness of deep brain stimulation (DBS) in early-stage Parkinson's disease (PD). Researchers suggested that DBS reduces the need for PD medication while improving long-term outcomes. Some background PD is a chronic disorder that affects brain cells. These cells lose their ability to control...
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In a nutshell This study looked at whether the use of high-dose (HD) brachytherapy (BT) and hypofractionated external beam radiotherapy (EBRT) plus androgen-deprivation therapy (ADT) as a means of treatment for very high-risk prostate cancer (PCa). The study found that this treatment had significant benefits for patients with high-risk...
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In a nutshell The study evaluated outcomes of the combination of carfilzomib (Kyprolis; K), dexamethasone (Decadron; d), and daratumumab (Darzalex; D) in patients with relapsed or refractory (r/r) multiple myeloma (MM). The authors found that KdD was safe and effective to improve progression-free survival (PFS) in such patients compared to...
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In a nutshell This study investigated if a dual-trigger treatment (DTT) improves pregnancy outcomes in older women with diminished ovarian reserve (DOR). They found that DTT improved in vitro fertilization (IVF) outcomes in these women. Some background In vitro fertilization (IVF) is an assisted reproductive technique (ART). The first step of...
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