In a nutshell This study aimed to investigate if venetoclax and intense chemotherapy is a safe and effective treatment in older patients with acute myeloid leukemia. This study concluded that this treatment was safe and effective in these patients. Some background Venetoclax (Venclexta) is a...
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In a nutshell This trial is being carried out to assess the effectiveness of atezolizumab (Tecentriq) in combination with cabozantinib (Cabometyx) versus docetaxel (Taxotere) in patients with metastatic non-small cell lung cancer (NSCLC) which has previously been treated with immunotherapy and platinum-based chemotherapy....
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In a nutshell This trial is examining the effectiveness of low-intensity shockwave therapy (LIST) on patients with erectile dysfunction (ED). The main outcome will be the change in ED after 1 month of treatment. This study is being conducted in Virginia, US. The details ED (or impotence) affects 18 million men in the US. It consists of the inability...
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In a nutshell This trial is looking to assess the effectiveness of ME-401 for relapsed follicular lymphoma (FL) after the failure of two or more therapies. The main outcome to be measured in this trial is the percentage of patients whose cancer shrinks or disappears after treatment. The details FL is a type of non-Hodgkin lymphoma....
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In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation. The authors found that sorafenib maintenance therapy decreased the risks of relapse and mortality after HSCT in such...
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In a nutshell This study aimed to investigate the outcomes and side effects of ibrutinib in patients with chronic lymphocytic leukemia in the real-world setting. This study concluded that the outcomes for these patients in the real-world setting were similar to clinical trials but the rate of side...
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In a nutshell This study looked at the effectiveness of rituxumab (Rituxan) with lenalidomide (Revlimid) for untreated follicular lymphoma (FL). It found that this treatment was more effective than rituxumab with chemotherapy. They also found that blood tests of trace FL can predict outcomes. Some background Follicular lymphoma (FL) is a slow-growing...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of ATI-450 in patients with rheumatoid arthritis (RA). The main outcomes will be the number of side effects and the change in disease activity (DA). This trial is recruiting at several locations in the United States. The details Rheumatoid...
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In a nutshell This phase 2 trial is examining the effectiveness of TAS-102 (Lonsurf) plus oxaliplatin (Eloxatin) in the treatment of metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured will be the overall response to the treatment rate. This study is being conducted in New Jersey, US. The details...
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In a nutshell This study is looking to examine the effectiveness of durvalumab (Imfinzi) and consolidation stereotactic body radiation therapy (SBRT) after chemoradiation for locally advanced stage III non-small-cell lung cancer (NSCLC). The main outcomes to be measured are the occurrence of side effects and the survival without cancer...
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In a nutshell This study was carried out in order to assess the safety and effectiveness of alirocumab (Praluent) in patients with homozygous familial hypercholesterolemia (FHC). The study found that these patients saw a significant reduction in cholesterol levels with the use of alirocumab. Some background Homozygous FHC is a genetic...
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In a nutshell This trial was carried out to assess the effectiveness of anlotinib (AL3818) on different subtypes of non-small cell lung cancer (NSCLC). The trial demonstrated that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with adenocarcinoma (ACC) and tended to improve survival in...
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