In a nutshell This study aimed to assess the effectiveness and safety of two doses of cabazitaxel (Jevtana) (20 or 25 mg/m2) in the treatment of castration-resistant prostate cancer (CRPC) in the real-world practice. The study found that a lower dose of cabazitaxel benefited patients at high risk of having side...
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In a nutshell This article looked at the effectiveness of gefitinib (Iressa) combined with chemotherapy when compared to a chemotherapy aline in the treatment of non-small cell lung cancer (NSCLC). The authors found that the addition of gefitinib to a chemotherapy increased the progression-free survival (PFS) of these...
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In a nutshell This study observed the effects of physical activity on patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) by using the supervision of a physiotherapist (PT) and additional digital monitoring. It showed that the multi-component procedures can help improve pain and the level of daily activity in these...
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In a nutshell The study evaluated the outcomes of immunoglobulin replacement (IgR) therapy in patients with B-cell non-Hodgkin lymphoma (B-NHL) and immunodeficiency, who were previously treated with rituximab (Rituxan). The authors found that IgR was safe and effective to increase serum immunoglobulins in such patients. Some background B-NHL happens...
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In a nutshell This article was carried out to analyze trials carried out in order to assess the role of maintenance therapy in transplant-ineligible (TI) patients with multiple myeloma (MM) following induction therapy. The authors found that maintenance therapy increases survival without disease worsening in these patients. Some background MM is...
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In a nutshell This study assessed the use of daratumumab (Darzalex) plus bortezomib (Velcade)/dexamethasone (Dexasone) or D-Vd versus bortezomib/dexamethasone (Vd) alone as a treatment for patients with high-risk multiple myeloma (MM). The authors found that D-Vd was effective and showed good tolerability...
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In a nutshell This trial is aiming to examine the effectiveness and safety of atezolizumab (Tecentriq) and tiragolumab compared to durvalumab (Imfinzi) in stage III non-small-cell lung cancer (NSCLC) that cannot be surgically removed and has previously been treated with concurrent (at the same time) platinum-based chemoradiation therapy (CRT)....
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In a nutshell This trial is examining the best dose of speech entrainment therapy (SET) to treat aphasia (speech impairment) in stroke survivors. The main outcome will be the number of verbs per minute before and after treatment. This trial will be conducted in South Carolina and Utah, US. The details A stroke happens when the blood flow to the brain...
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In a nutshell This phase 3 trial will investigate the safety and effectiveness of switching from rituximab (Rituxan/Mabthera) to DRL_RI in patients with rheumatoid arthritis (RA). The main outcome will be the rate of side effects and anti-drug drug antibodies (ADAs). This study is recruiting at several locations in the United...
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In a nutshell This study reviewed the effectiveness of dopamine agonists (DAg) and MAO-B inhibitors in the treatment of patients with Parkinson's disease (PD). Researchers suggested that DAgs and selegiline alone or with levodopa were the best options to treat these patients. Some background Parkinson's disease (PD) is a chronic disorder...
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In a nutshell This study looked at the lung function of patients with classical Hodgkin lymphoma (HL) in the first years of remission. It found that these survivors had higher rates of lung damage. Some background HL is a cancer of the lymph nodes which most often affects children and young adults. HL has good outcomes, and most patients with HL will...
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In a nutshell This study aimed to investigate the real-world safety and effectiveness of brentuximab vedotin (BV) and bendamustine before stem cell transplant (SCT) for patients with relapsed or refractory classical Hodgkin lymphoma (cHL). This study concluded that this treatment is safe and effective as...
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