In a nutshell This study compared carbidopa–levodopa (CL) extended-release (ER) with immediate-release (IR) in patients with Parkinson's disease (PD) and dyskinesia (dys). Researchers suggested that conversion from CL-ER to CL-IR works best in patients without dys or with minor dys. Some background PD affects certain brain cells....
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In a nutshell This study is looking to trial the addition of a new form of vaccine called a neoantigen vaccine in combination with nab–paclitaxel (Abraxane), duvalumab (Imfinzi), and tremelimumab (CP-675,206), in patients with metastatic triple-negative breast cancer (mTNBC). The main outcome that will be measured is survival without the...
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In a nutshell This trial is looking at the effectiveness of Quad Shot (QS) radiation therapy (RT) to relieve symptoms in patients with advanced non-small-cell lung cancer (NSCLC). The main outcome that is to be measured is the occurrence of side effects over the course of 3-months. This trial is being carried out in New Jersey and New York,...
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In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including lung cancer. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated. These tumors...
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In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including prostate cancer. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated. These...
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In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including melanoma. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated....
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In a nutshell This controlled trial looked at adding exenatide (Byetta) to intensive insulin treatment for patients with type 2 diabetes (T2D) who still had high blood sugar. It found that the exenatide improved blood sugar control and reduced body weight in these patients. Some background T2D is a metabolic condition in which the body does not...
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In a nutshell This study investigated if orthostatic hypotension (OH) affects the effectiveness of rivastigmine (Exelon) in patients with Parkinson’s disease and dementia (PDD). Researchers suggested that rivastigmine is associated with better outcomes in patients with OH. Some background Parkinson’s disease (PD) is a chronic...
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In a nutshell This study investigated the effectiveness of urethral-sparing robotic-assisted prostate surgery (USRAP) in the treatment of benign prostatic hyperplasia (BPH). Researchers suggested that USRAP is a good and safe method for the treatment of these patients. Some background Prostatic hyperplasia consists of an enlarged prostate that results...
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In a nutshell This study investigated the effectiveness and safety of upadacitinib (Rinvoq) to abatacept (Orencia) for patients with rheumatoid arthritis (RA). The study showed that upadacitinib was more effective in lowering the disease activity score (DAS28) and in decreasing symptoms, but had more side...
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In a nutshell This study looked at the safety and effectiveness of atezolizumab (Tecentriq) compared to platinum-based chemotherapy for the treatment of advanced lung cancer. They found that atezolizumab improved survival compared to chemotherapy in these patients. Some background Lung cancer is classified based on how the tumor cells look...
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In a nutshell This study aimed to investigate the combination of zanubrutinib (Brukinsa) and obinutuzumab (Gazyva) in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and follicular lymphoma (FL). This study concluded that this combination was well tolerated and had promising responses in these patients. Some...
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