In a nutshell This trial is looking to examine the safety and effectiveness of a new drug called CYH33 in combination with olaparib (Lynparza) for the treatment of advanced solid tumors including prostate cancer. The main outcomes that are to be measured are side effects and the response rate to the treatment. This trial is being carried out in Houston,...
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In a nutshell This study aimed to investigate the outcomes for patients with multiple myeloma (MM) who were treated with pomalidomide (Pomalyst), bortezomib (Velcade), and dexamethasone (Decadron) after relapsing following lenalidomide (Revlimid) treatment. This study concluded that this treatment combination was effective in...
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In a nutshell This study was carried out to examine the effectiveness of olaparib (Lynparza) for the treatment of metastatic breast cancer (MBC; cancer that has spread) with gene mutations (abnormalities). The authors found that this treatment was effective for patients with MBC with BRCA1/2 mutations. Some background Breast cancer (BC) is one of the...
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In a nutshell This study was carried out to assess the long-term safety and effectiveness of magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) in patients with localized prostate cancer. The authors found that TULSA was safe and effective, with preserved quality of life. Some background Prostate cancer is one...
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In a nutshell This study aimed to investigate if the combination of recombinant human granulocyte colony-stimulating factor (rhG-CSF; Filgrastim) and decitabine (Dacogen) would be effective in preventing relapse after transplant for patients with high-risk (HR) acute myeloid leukemia (AML). This study...
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In a nutshell This study compared the use of radiotherapy for prostate cancer in two areas: the prostate only, or the whole pelvis. The results showed that, for high-risk patients, radiotherapy of the whole pelvis improved patient outcomes. Some background For patients with medium or high-risk prostate cancer, the standard treatment is...
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In a nutshell This study investigated the long-term effectiveness and safety of certolizumab pegol (Cimzia) in patients with rheumatoid arthritis (RA) from a real-world practice. They found that this medication was safe and patients had a sustained response. Some background Rheumatoid arthritis (RA) is a chronic condition. It is...
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In a nutshell This study looked at using the anti-inflammatory progestin dienogest (Visanne) prior to in vitro fertilization (IVF) for patients with endometriosis with a previously failed IVF. It found that dienogest improved IVF outcomes in these women. Some background Endometriosis is a chronic illness in which cells from the lining of the uterus...
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In a nutshell This study investigated if giving patients with aggressive multiple myeloma (MM) a combination of selinexor (Xpovio), bortezomib (Velcade), and dexamethasone (Ozurdex) could improve their survival. The study suggested that this combination improved patients’ outcomes. Some background Multiple Myeloma (MM) is an...
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In a nutshell This review compared mild-dose ovarian stimulation (OS) for in vitro fertilization (IVF) to standard higher dose OS. It found that mild OS has fewer side effects and similar birth rates. Some background The first stage of the infertility treatment IVF is to stimulate the ovaries. The most common type of medication used is gonadotropin...
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In a nutshell This study aimed to investigate the safety and effectiveness of tisagenlecleucel (TL; Kymriah) in a real-world setting as a treatment for acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). This study concluded that TL has similar effectiveness and improved safety in a real-world setting when compared to a trial...
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In a nutshell This study aimed to investigate the safety and effectiveness of tisagenlecleucel (TL; Kymriah) in a real-world setting as a treatment for acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). This study concluded that TL has similar effectiveness and improved safety in a real-world...
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