In a nutshell This trial was carried out to examine the effectiveness of switching from upadacitinib (UPA; Rinvoq) to adalimumab (ADA; Humira) and from ADA to UPA following insufficient response in patients with rheumatoid arthritis (RA). The authors found that patients who do not respond to UPA or ADA can be...
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In a nutshell This study investigated the effectiveness of bevacizumab plus chemotherapy and deep electro-hyperthermia (DEH) for advanced colon cancer (CC). Researchers suggested that this treatment improves the outcomes of these patients. Some background Colorectal cancer is a common cancer worldwide. Around 50-60% of these patients...
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In a nutshell This study reported the extended follow-up outcomes on RestoreX effectiveness in men with Peyronie´s disease (PD). Researchers suggested that RestoreX improves the length, curve, and sexual function of these patients. Some background PD is caused by the formation of scar tissue inside the penis. This can result in a bent erect...
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In a nutshell This study investigated the effectiveness of irinotecan (Camptosar) with and without cetuximab (Erbitux) in the treatment of metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that combined treatment improves the outcomes of these patients. Some background Colorectal cancer (CRC) is one of...
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In a nutshell The study compared outcomes of lorlatinib (Lorbrena) with crizotinib (Xalkori) in patients with previously untreated advanced non-small-cell lung cancer (NSCLC) with ALK mutations (genetic abnormalities). The main finding was that patients receiving lorlatinib had longer progression-free survival (PFS) and a higher response in the...
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In a nutshell This study investigated renin inhibitors (RI) and angiotensin-converting enzyme inhibitors (ACEI) in hypertension. They found that RI may reduce blood pressure (BP) more than ACEI, but mortality and heart attack risk was similar for both drug types. Some background Hypertension or high blood pressure (BP) is a common condition....
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In a nutshell The authors looked at the use of busulfan (Myleran), melphalan (Alkeran), and bortezomib (Velcade) compared with melphalan only for autologous stem cell transplantation (autoSCT) in the treatment of multiple myeloma (MM). The authors concluded that using this drug combination leads to an...
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In a nutshell This trial is evaluating the effectiveness and safety of combining nivolumab (Opdivo) with docetaxel (Taxotere) and prednisone (Deltasone) in men with metastatic castration-resistant prostate cancer (mCRPC). The main outcomes to be evaluated will be survival without cancer worsening and overall survival. The details CRPC is a difficult...
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In a nutshell This phase 2 clinical trial is evaluating the safety and effectiveness of targeted therapy TAS-120 (futibatinib) alone or in combination with fulvestrant (Faslodex) in patients with metastatic breast cancer (mBC). The main outcomes to be evaluated will be the response rate and survival without cancer worsening. The details Breast...
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In a nutshell This trial is evaluating the safety and effectiveness of experimental treatment REGN5093 in patients with advanced non-small-cell lung cancer (NSCLC). The main outcomes to be evaluated will be the number of patients who experience side effects, the maximum dose without significant side effects, and response to treatment. This trial is...
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In a nutshell This review looked at the effect of a fiber-rich diet on the microbiome for patients with diabetes. It found that high-fiber diets led to more healthy bacteria in the gut, and may improve glucose control. Some background The microbiome consists of bacteria and other microorganisms which live on the skin and in the gut. A healthy gut...
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In a nutshell This trial is looking to examine the safety and effectiveness of a new drug called CYH33 in combination with olaparib (Lynparza) for the treatment of advanced solid tumors including breast cancer. The main outcomes that are to be measured are side effects and the response rate to the treatment. This trial is being carried out in...
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