In a nutshell This study looked at the use of sotagliflozin (Zynquista) in patients with poorly controlled type 2 diabetes (T2D) and chronic kidney disease (CKD). It found that patients taking sotagliflozin was associated with a lower risk of heart attack, stroke, or death. Some background Patients with T2D and CKD are...
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In a nutshell This study aimed to investigate the combination of dasatinib (Sprycel) and blinatumomab (Blincyto) as a first-line therapy in patients with Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL). This study concluded that this treatment combination led to better response and survival in these...
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In a nutshell This study compared the effects of intensity-modulated radiation therapy (IMRT) with a simultaneously integrated boost (SIB) to conventional radiotherapy (CRT) with a sequential boost (SeqB) following breast-conserving surgery (BCS) in patients with breast cancer. The data showed that both radiotherapy techniques...
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In a nutshell This study investigated the impact of the D-Rd regimen including daratumumab (Darzalex) combined with lenalidomide (Revlimid) and dexamethasone (Decadron) on the quality of life of patients with multiple myeloma (MM) who cannot undergo a transplant. The study showed that patients who received D-Rd reported lower levels of...
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In a nutshell This study investigated the effectiveness and safety of pembrolizumab (Keytruda) plus chemotherapy in patients with inoperable or metastatic triple-negative breast cancer. The data showed that the combination is effective in improving progression-free survival in these patients. Some background Triple-negative breast cancer (TNBC)...
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In a nutshell This study reviewed the effectiveness of citicoline (CIT; Neurocoline) in improving symptoms of Parkinson’s disease (PD). Researchers suggested that CIT improved the symptoms of these patients. Some background More than 10 million people worldwide live with PD. It affects brain cells which lose their abilities to control body...
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In a nutshell This study evaluated the treatment schedule for panobinostat (Farydak) tablets combines with subcutaneous (injections under the skin) bortezomib (Velcade) and dexamethasone (Ozurdex) tablets in patients with relapsed/refractory (R/R) multiple myeloma (MM). The study found that 20mg of panobinostat should be given twice...
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In a nutshell This article looked at the use of ejaculatory dysfunction (EjD) as a side effect of minimally invasive procedures for the treatment of benign prostatic hyperplasia (BPH). The authors found that the choice of treatment should be made by doctors together with their patients and should be based on effectiveness and...
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In a nutshell This study examined the long-term effectiveness and safety of proton therapy for localized prostate cancer. The data showed that proton therapy has favorable outcomes in these patients. Some background Localized prostate cancer (PCa) is a form of cancer that has not spread beyond the prostate gland. PCa can be treated by...
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In a nutshell The study evaluated the timing of radiotherapy (RT) and immune-checkpoint therapy (ICT) on the outcomes of patients with brain metastasis (BrM) resulting from melanoma and non-small cell lung cancer (NSCLC). The authors found that RT and ICT given at the same time may improve response and delay recurrence in these patients. Some...
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In a nutshell The study evaluated the timing of radiotherapy (RT) and immune-checkpoint therapy (ICT) on the outcomes of patients with brain metastasis (BrM) resulting from melanoma and non-small cell lung cancer (NSCLC). The authors found that RT and ICT given at the same time may improve response and delay recurrence in these patients. Some background...
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In a nutshell The study evaluated the optimal timing of surgery for colorectal cancer liver metastasis (CRLM) after chemotherapy (CT). The main finding was that surgery within 5 weeks after CT may improve patients' outcomes. Some background Chemotherapy (CT) is used before surgery to remove tumors to reduce tumor size. This is...
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