In a nutshell This trial compared the use of standard paclitaxel (SP; Taxol) versus a new nanoparticle micellar preparation of paclitaxel (NmP) as a first-line treatment for non-small cell lung cancer (NSCLC). The authors found that NmP had better effectiveness and safety in treating NSCLC than SP. Some...
Read More
In a nutshell This clinical trial looked at the effect of barberry on patients with high blood pressure. It found that barberry increased arteries’ flexibility and reduced inflammation. Some background As the heart pumps blood, the arteries expand and contract to accommodate the changing volume of blood and maintain a steady blood pressure. When...
Read More
In a nutshell This study investigated the effectiveness and safety of GDP (gemcitabine, dexamethasone, and cisplatin) and ICE (ifosfamide, carboplatin, and etoposide) regimens as salvage therapy in patients with relapsed/refractory aggressive lymphoma. The data showed that both the GDP and ICE regimens are suitable options for relapsed/refractory...
Read More
In a nutshell This study investigated the effectiveness and safety of GDP (gemcitabine, dexamethasone, and cisplatin) and ICE (ifosfamide, carboplatin, and etoposide) regimens as salvage therapy in patients with relapsed/refractory aggressive lymphoma. The data showed that both the GDP and ICE regimens are suitable options for relapsed/refractory...
Read More
In a nutshell This study aimed to investigate if chemotherapy (CT) conditioning could replace total body irradiation (TBI) before stem cell transplant (SCT) in children with acute lymphoblastic leukemia (ALL). This study concluded that TBI in combination with CT was safer and more effective than CT conditioning alone in these...
Read More
In a nutshell This trial was carried to look at the use of erlotinib (Tarceva) with radiotherapy (RT) compared to standard treatment for EGFR-positive non-small cell lung cancer (NSCLC) that cannot be removed surgically. The authors found that erlotinib and RT improved survival without cancer worsening in these patients. Some...
Read More
In a nutshell This study compared 1-year fixed-duration versus continuous nivolumab (Opdivo) for the treatment of previously treated advanced non-small-cell lung cancer (NSCLC). The authors found that continuing nivolumab beyond a fixed duration of 1-year may improve patient outcomes. Some background NSCLC is the most common form of lung cancer....
Read More
In a nutshell This study compared weekly semaglutide (Ozempic) and daily sitagliptin (Januvia) for type 2 diabetes (T2D) in an Asian population. It showed that patients treated with semaglutide had a greater improvement in T2D control and increased weight loss compared to those treated with sitagliptin. Some...
Read More
In a nutshell This study looked at the effect of treatment with polyethylene glycol loxenatide (PEX168) alone in patients with poorly controlled type 2 diabetes (T2D). They found that PEX168 significantly improved blood glucose control in these patients. Some background Blood glucose is controlled by many hormones. The most...
Read More
In a nutshell This study compared the use of pembrolizumab (Keytruda) to chemotherapy for the treatment of patients with colorectal cancer (CRC) and high microsatellite instability (MI). This study showed that patients who received pembrolizumab had a better outcome than those who were given chemotherapy. Some background Patients who are...
Read More
In a nutshell This study compared the effectiveness of regorafenib (Stivarga), trifluridine/tipiracil (TFTP; Lonsurf), and combinations of these drugs in the treatment of patients with inoperable colorectal cancer. Researchers suggested that a combination of TFTP and regorafenib is associated with longer survival and fewer side effects. Some...
Read More
In a nutshell The aim of this study was to check the safety and effectiveness of the combination of ipilimumab (Yervoy) and radiotherapy (RT) in patients with high-risk melanoma. The study found that ipilimumab + RT was safe and had good responses in these patients. Some background Melanoma is a type of skin cancer. First line therapy for...
Read More
