In a nutshell This study aimed to investigate the long-term outcomes of sorafenib (Nexavar) treatment and maintenance therapy in patients with acute myeloid leukemia (AML). This study concluded that the addition of sorafenib to chemotherapy led to better outcomes for these patients. Some background...
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In a nutshell This study investigated the health-related quality of life (HRQoL) for patients with relapsed/refractory (RR) multiple myeloma (MM) patients treated with D-Vd (daratumumab, bortezomib, and dexamethasone) compared to Vd (bortezomid and dexamethasone). The study showed that HRQoL did not decrease for 8 therapy cycles and long-term...
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In a nutshell This study evaluated whether chemoradiotherapy (CRT) before surgery improves the outcomes of patients with stage II-III colorectal cancer (CRC). The study found that CRT before surgery may not be needed in certain patients with low-risk disease. Some background CRC is the third most common cancer worldwide. The standard therapy for...
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In a nutshell This study looked at the outcomes of durvalumab (Imfinzi) in patients with unresectable (cannot be surgically removed) stage 3 non-small cell lung cancer (NSCLC) who received different combinations of chemoradiotherapy (CRT) previously. The authors found that the use of durvalumab improved survival in all patients previously treated...
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In a nutshell This trial is looking to trial a treatment combination of olaparib (Lynparza), durvalumab (Imfinzi), radiation therapy (RT), and chemotherapy (CT) to treat patients with extensive-stage (ES) small-cell lung cancer (SCLC). The main outcomes to be measured are side effects and survival. This trial is being carried out in Texas,...
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In a nutshell This trial is looking to examine the use of a new treatment software (UroNAV Ablation) system in treating confined prostate cancer with cryoablation. The main outcomes to be measured will be device/treatment-related complications and tumor control. This trial is being carried out in New York, US. The details Localized...
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In a nutshell This study investigated the effectiveness of subthalamic nucleus (SN) deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Researchers suggested that SN-DBS is safe and associated with improved treatment outcomes for these patients. Some background PD affects the brain cells. The brain cells of patients...
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In a nutshell This study investigated the effectiveness of safinamide (Xadago) in treating urinary symptoms of patients with Parkinson´s disease (PD). Researchers suggested that adding safinamide to PD treatment improves urinary symptoms in these patients. Some background PD is a brain disease where the brain loses the capacity in...
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In a nutshell This study reviewed and compared the effectiveness of convective water vapor energy therapy (WAVE) with prostatic urethral lift (PUL) in men with benign prostatic hyperplasia (BPH). The data showed that WAVE treatment improved the urinary flow rate and durability of response compared to PUL treatment. Some background BPH is a...
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In a nutshell The aim of this study was to evaluate the safety and effectiveness of autologous stem cell transplant (ASCT) in patients with multiple myeloma (MM) aged 75 or older. The study found that ASCT was safe and effective for certain patients in this age group. Some background MM is a type of blood cancer that impacts bone marrow. Therapy for...
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In a nutshell The aim of this study was to evaluate the safety and effectiveness of a type of chimeric antigen receptor (CAR)-T-cell therapy that targets B-cell maturation antigens (BCMA) for patients with multiple myeloma (MM). The study found that patients had a very good response to therapy, while there was a high risk of side...
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In a nutshell This study evaluated the use of immunotherapy (IT) and/or radiotherapy (RT) for the treatment of melanoma with brain metastasis (MBM). The study found that combining IT with RT improved survival outcomes for these patients. Some background The spread of cancer from the original tumor to other parts of the body is called metastasis....
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