In a nutshell This study compared the long-term effectiveness of integrated intensity-modulated radiation therapy (IMRT) and segmented 3D-conventional radiotherapy (3D-CRT) following breast-removal surgery (radical mastectomy) in patients with breast cancer (BC). The data showed that integrated IMRT reduced the recurrence rate in the long-term with...
Read MoreIs nivolumab safe and effective for the treatment of advanced melanoma in the real-world clinical practice?
In a nutshell This study evaluated the safety and effectiveness of nivolumab (Opdivo) in patients with advanced melanoma in a real-world practice. The study found that the safety and effectiveness of nivolumab in these patients were similar to that reported in clinical trials. Some background Melanoma is a form of skin cancer. In more advanced...
Read MoreIs olmutinib effective in treating T790M-positive unresponsive non-small cell lung cancer?
In a nutshell This article looked at the use of olmutinib (Olita) in the treatment of T790M-positive non-small cell lung cancer (NSCLC) that was previously unresponsive to a tyrosine kinase inhibitor (TKI). The authors concluded that olmutinib had clinical activity and manageable side effects in these patients. Some background NSCLC accounts for...
Read MoreEvaluating surgery and chemotherapy versus chemotherapy alone for the treatment of metastatic colorectal cancer.
In a nutshell This study evaluated whether surgery of colorectal cancer (CRC) followed by chemotherapy (CT) improved the outcomes of patients with metastatic (spread) CRC compared to CT alone. The study found that there was no difference in patients' outcomes whether surgery was given or not. Some background CRC is the third most common cancer...
Read MoreCombining venetoclax and navitoclax with chemotherapy in patients with relapsed/refractory acute lymphoblastic leukemia and lymphoblastic lymphoma
In a nutshell This study aimed to investigate the safety and effectiveness of venetoclax (Venclexta) and low-dose navitoclax (ABT-263) in combination with chemotherapy in patients with relapsed/refractory (r/r) acute lymphoblastic leukemia (ALL). This study concluded that this treatment option was well tolerated and...
Read MoreDoes cannabis use lower blood pressure in older adults?
In a nutshell This study compared blood pressure (BP) in older adults, before and after using medicinal cannabis for three months. It found that using medical cannabis resulted in a reduction of BP. Some background Medicinal cannabis such as cannabidiol use is increasing, particularly amongst older adults. It is often prescribed for...
Read MoreEvaluating the effectiveness of BGD therapy in relapsed/refractory Hodgkin lymphoma
In a nutshell This study aimed to investigate the safety and effectiveness of the BGD (bendamustine, gemcitabine, and dexamethasone) regimen in patients with previously treated Hodgkin lymphoma (HL). This study concluded that BGD is well-tolerated and highly effective in these patients. Some background Hodgkin lymphoma (HL) is a cancer that...
Read MoreRelapsed or refractory Hodgkin lymphoma: how does stopping and restarting nivolumab impact patient outcomes?
In a nutshell This study aimed to evaluate the safety and effectiveness of stopping and restarting nivolumab (Opdivo) in patients with relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). The authors concluded that nivolumab retreatment is well tolerated and effective in patients who achieved complete response (CR; complete...
Read MoreEvaluating etanercept for IVF implantation
In a nutshell This study looked at etanercept (Enbrel) for women who have had repeated unsuccessful in vitro fertilization (IVF). It found that etanercept led to good pregnancy rates in these patients. Some background The uterus forms a connection between the vagina, which is open to the outside, and the inside of the body. If harmful bacteria...
Read MoreA reduction in salt intake improves the symptoms of overactive bladder
In a nutshell This study investigated the effects of salt intake reduction on overactive bladder (OAB) symptoms. Researchers suggested that the reduction in salt intake improved OAB symptoms. Some background OAB consists of urinary urgency with or without urge incontinence (leakage of urine). It is present in 16 to 19% of patients with urinary...
Read MoreCT-guided radioactive implant improves the outcomes of locally advanced rectal cancer
In a nutshell This study investigated the effectiveness and safety of computed tomography (CT)-guided radioactive 125Iodine (RI) implantation in patients with recurrent locally advanced rectal cancer (LARC). Researchers suggested that CT-guided RI implantation is a good and safe treatment for patients with LARC that came back...
Read MoreAlternative treatments for erectile dysfunction: A review
In a nutshell This study reviewed several different treatments for erectile dysfunction (ED). Researchers suggested that alternative treatments combined with phosphodiesterase 5 inhibitors (PDE5i) are associated with improved effectiveness. Some background ED is one of the most frequent sexual health conditions. It affects around 18 million...
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