In a nutshell This study investigated the effectiveness and safety of inotuzumab ozogamicin (Besponsa; INO) in patients with relapsed/refractory (r/r) acute lymphocytic leukemia (ALL) and non-Hodgkin lymphoma (NHL). The data showed that the treatment had good effectiveness and manageable side effects for these patients. Some background A high number...
Read MoreComparing the safety and effectiveness of pyrotinib versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer
In a nutshell This study compared the safety and effectiveness of pyrotinib (SHR-1258) plus capecitabine (Xeloda) versus lapatinib (Tyverb) plus capecitabine in patients with metastatic human epidermal growth factor (HER2)-positive breast cancer (BC) after previous treatment with trastuzumab (Herceptin) and chemotherapy. The data...
Read MoreCan a keto diet benefit patients with diabetes and obesity?
In a nutshell This study looked at how a very-low-calorie ketogenic diet affected people with type 2 diabetes (T2D) and obesity. It found that the ketogenic diet improved weight, blood sugar, and quality of life more than a standard low-calorie diet. Some background Diabetes involves excessive glucose (sugar) in the blood and can reduce overall...
Read MoreComparing TVT and TVT-O in women with stress urinary incontinence
In a nutshell This study aimed to compare the effectiveness and complications of bottom-up tension-free vaginal tape (TVT) and inside-out tension-free vaginal tape – obturator (TVT-O) in women with stress urinary incontinence (SUI). This study suggested that TVT and TVT-O had similar effectiveness but TVT was associated with fewer chronic...
Read MoreCan using ultra-rapid lispro in patients with type 1 diabetes using subcutaneous insulin infusion improve glucose control after meals?
In a nutshell This study compared the effectiveness and safety of ultra-rapid lispro (URLi; LyumjevTM) to lispro (Humalog) in patients with type 1 diabetes (T1D) on continuous subcutaneous insulin infusion (CSII). The authors concluded that URLi was similarly effective and provided improved postprandial glucose (PPG) control with reduced hypoglycemia in...
Read MoreCombined therapies for erectile dysfunction: A review
In a nutshell This review compared the outcomes of different combined therapy for erectile dysfunction (ED). Researchers suggested that a combination of phosphodiesterase 5 inhibitor (PDE5i) and antioxidants is safe and associated with improved outcomes in these patients. Some background ED consists of the inability of getting and...
Read MoreTibial nerve stimulation improves urinary symptoms in patients with Parkinson´s disease
In a nutshell This study investigated the effectiveness of percutaneous tibial nerve stimulation (PTNS) treatment in patients with Parkinson's disease (PD) and lower urinary tract symptoms (LUTS). Researchers suggested that PTNS is associated with improved outcomes in these patients. Some background PD is a chronic disease that affects over...
Read MoreComparing nilotinib and dasatinib as second line treatment in patients with chronic myeloid leukemia in a real-life setting
In a nutshell This study aimed to compare dasatinib (Sprycel) and nilotinib (Tasigna) as second-line treatments for patients with chronic-phase (CP) chronic myeloid leukemia (CML) in a real-life setting. This study concluded that both dasatinib and nilotinib are equally effective and well...
Read MoreEvaluating treatment options after surgery for patients with high-risk melanoma.
In a nutshell The aim of this study was to evaluate different types of therapy after surgery for patients with high-risk melanoma. The study found that add-on targeted therapy or immunotherapy was likely to decrease the risk of disease progression in these patients. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
Read MoreIs VD-PACE and immunotherapy a good salvage therapy for relapsed/refractory multiple myeloma?
In a nutshell The aim of this study was to evaluate if the VD-PACE (bortezomib, dexamethasone, cisplatin, doxorubicin, cyclophosphamide, etoposide) regimen in combination with immunotherapy was effective as a salvage therapy for patients with relapsed or refractory (r/r) multiple myeloma (MM). The study found this salvage therapy option...
Read MoreCan Vitamin B12 improve nerve function in patients with diabetes and nerve dysfunction?
In a nutshell This study looked at the effectiveness of vitamin B12 in people with type 2 diabetes (T2D) and loss of nerve function. It found that the vitamin improved pain, sensation, and quality of life in these patients. Some background T2D is a condition that involves high levels of glucose (sugar) in the blood. Over time, high blood sugar can...
Read MoreHow effective is umbralisib as treatment for patients with relapsed or refractory low-grade lymphoma?
In a nutshell The authors assessed the safety and effectiveness of umbralisib (Ukoniq) in patients with relapsed or refractory (r/r) indolent (low-grade) non-Hodgkin lymphoma (iNHL). The study concluded that umbralisib was well tolerated and effective for patients with r/r iNHL. Some background iNHL is a slow-growing cancer of...
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