In a nutshell The aim of this study was to evaluate the outcomes of combining stereotactic radiosurgery (SRS) with BRAF inhibitors for brain metastasis in patients with melanoma. The study found that adding BRAF inhibitors to STS improved patient outcomes. Some background Melanoma is one of the most aggressive forms of skin cancer....
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In a nutshell The aim of this study was to evaluate the impact of adding oxaliplatin (Eloxatin) to the chemotherapy regimen tegafur uracil (UFT)/leucovorin (LV; folinic acid) for patients that had surgery for colorectal cancer (CRC). The study found that the addition of oxaliplatin to UFT/LV improved patient outcomes. Some background CRC can...
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In a nutshell This study explored the use of aquablation for the removal of prostate tissue in patients with benign prostatic obstruction (BPO). The results confirmed the safe and effective use of aquablation as an intervention for BPO. Some background BPO involves the increase of the prostate gland that blocks urine flow out of the bladder. This...
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In a nutshell This study investigated the outcomes and effectiveness of administering additional (adjuvant) androgen deprivation therapy (A-ADT) for long-term after radiotherapy (RT) in high-risk or very high-risk locally advanced prostate cancer (LAPC). The study found that the addition of A-ADT longer than 1 year after RT showed good treatment outcomes...
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In a nutshell This study investigated the effectiveness and safety of combining vorinostat (Zolinza) with bortezomib (Velcade) and dexamethasone (Decadron) in patients with relapsed multiple myeloma (MM). The data showed that the treatment combination had promising effectiveness but with side effects. Some background Multiple...
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In a nutshell This study aimed to evaluate the safety, optimal dosage, and effectiveness of glofitamab (RO7082859) for the treatment of patients with relapsed or refractory (r/r) B-cell non-Hodgkin lymphoma (B-NHL). The authors concluded that glofitamab treatment on its own or in combination with other immunotherapies is safe and effective in these...
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In a nutshell The aim of this study was to evaluate the safety and effectiveness of a cancer vaccine for patients with advanced melanoma. The study found that the vaccine was safe and increased patient survival without worsening of the disease. Some background Treatment for early-stage melanoma includes surgery to remove the tumor. For...
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In a nutshell This study aimed to investigate the effectiveness of idelalisib (Zydelig) and rituximab (Rituxan) in patients with relapsed/refractory (r/r) chronic lymphocytic leukemia (CLL) in a real-life setting. This study concluded that this treatment in a real-life setting was just as effective as in a clinical trial...
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In a nutshell This study compared the effect of two doses of semaglutide (Ozempic), 2.4 mg and 1.0 mg to a placebo, given once weekly subcutaneously (sc; injected under the skin) to adults with overweight or obesity and type 2 diabetes (T2D). The authors concluded that patients treated with 2.4 mg of semaglutide once weekly showed a higher...
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In a nutshell This study provided an updated 5-year assessment of treatment-free remission (TFR) after frontline nilotinib (Tasigna) treatment in patients with chronic-phase (CP) chronic myeloid leukemia (CML). The data showed sustained, long-term high TFR rates with effectiveness and safety in these patients. Some background Long-term treatments...
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In a nutshell This trial was carried out to compare osimertinib (Tagrisso) with other EGFR inhibitors to examine its effectiveness in treating advanced non-small cell lung cancer (NSCLC). The authors found that this treatment was effective in increasing survival without cancer worsening in these patients. Some background NSCLC is...
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In a nutshell This study investigated the effectiveness and safety of inotuzumab ozogamicin (Besponsa; INO) in patients with relapsed/refractory (r/r) acute lymphocytic leukemia (ALL) and non-Hodgkin lymphoma (NHL). The data showed that the treatment had good effectiveness and manageable side effects for these patients. Some background A high number...
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