In a nutshell The aim of this study was to evaluate the safety and effectiveness of adding selinexor (X; Xpovio) to the Vd (bortezomib and dexamethasone) regimen in older, frail patients with multiple myeloma (MM). The study found that the addition of selinexor to Vd (XVd) was safe and gave older, more frail patients a better...
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In a nutshell This study compared the effectiveness and safety of single-incision slings (SIS) and transobturator slings (TOS) in women with stress urinary incontinence (SUI) and sphincter deficiency. Researchers suggested that SIS and TOS had similar surgical outcomes in these patients. Some background SUI is common in adult women. It involves the...
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In a nutshell This study reviewed regional treatment options for patients with colorectal cancer (CRC) and liver metastases (LM; spread to the liver). Some background CRC is the third most common cancer in the world. The most common organ where the cancer spreads is the liver. Surgery is the standard treatment for LM....
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In a nutshell This study examined the effectiveness of adding henagliflozin (SHR3824) to metformin (Glucophage) in patients with uncontrolled type 2 diabetes (T2D). The authors concluded that the addition of 5 mg or 10 mg of henagliflozin to metformin was well-tolerated and effective in these patients. Some background...
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In a nutshell This study evaluated the clinical effectiveness and safety of daratumumab (Darzalex) treatment for patients with heavily pre-treated multiple myeloma (MM) in a real-world setting. The study showed that daratumumab is safe and effective in these patients. Some background MM is a type of cancer that affects white blood...
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In a nutshell This study aimed to compare the safety and effectiveness of intensive and less-intensive therapy for older adults with acute myeloid leukemia (AML). This study concluded that intensive therapy may lead to better outcomes for these patients when compared to less-intensive therapy. Some background Older patients with...
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In a nutshell This study aimed to investigate if acalabrutinib (Calquence) was suitable for patients with relapsed/refractory (r/r) chronic lymphocytic leukemia (CLL) who are intolerant to ibrutinib (Imbruvica). This study concluded that acalabrutinib was effective and well tolerated in these patients. Some...
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In a nutshell The aim of this study was to investigate the role of chemotherapy (CT) after surgery in patients with rectal cancer. The study suggests that CT after surgery could improve patient outcomes. Some background Rectal cancer can be treated with surgery to remove the tumor. In general, patients are given CT before the...
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In a nutshell This study looked at the acceptability and effect on blood pressure of replacing normal salt with a salt substitute. It found that the salt substitute resulted in a drop in blood pressure compared to normal salt. Some background High salt intake is a risk factor for high blood pressure. Replacing salt with salt substitutes...
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In a nutshell The aim of this study was to evaluate the long-term safety and effectiveness of adding daratumumab (Darzalex) to RVd (lenalidomide/bortezomib/dexamethasone) therapy, followed by D-R (daratumumab/lenalidomide) maintenance for patients with newly diagnosed multiple myeloma (MM). The study found that this treatment was well tolerated...
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In a nutshell This trial looked at nivolumab (Opdivo) plus ipilimumab (Yervoy) combined with 2 cycles of chemotherapy as treatment for patients with non-small cell lung cancer (NSCLC). The authors found that this combination provided an improved overall survival versus chemotherapy-only regimens. Some background NSCLC is responsible for 85% of...
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In a nutshell The study investigated the effectiveness of combining sipuleucel-T (Provenge) with radium-223 (Xofigo) therapy in men with castration-resistant prostate cancer (CRPC) that has spread to the bones. The key finding was that the combination therapy improved the survival rates of these patients. Some background Prostate cancer often...
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