In a nutshell This study presents 5-year results for the targeted antibody therapy brentuximab vedotin (BV; Adcetris) for patients with advanced Hodgkin lymphoma (HL) who had not been previously treated. It found that BV with chemotherapy led to less recurrence of HL compared to chemotherapy alone. Some background The outcomes for patients with the...
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In a nutshell This study compared how the thickness of the uterine lining affected outcomes from two protocols for in vitro fertilization (IVF). It found that the GnRH antagonist protocol had better outcomes when the lining was of medium thickness. The long GnRH agonist protocol had better outcomes when there was a thick lining. Some background IVF is...
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In a nutshell This study reported the long-term effectiveness and safety outcomes of changing treatment intensity after a PET scan for patients with advanced-stage Hodgkin lymphoma (HL). The data showed that reducing treatment intensity after a negative PET scan and continuing standard-dose treatment after a positive PET scan was safe and effective over...
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In a nutshell This study investigated the effectiveness and safety of total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (CRT) for the treatment of patients with locally advanced rectal cancer (LARC). The data showed that TNT was associated with improved outcomes compared with standard CRT for these patients. Some background...
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In a nutshell This study evaluated the effectiveness and safety of adding daratumumab (Darzalex) to pomalidomide (Pomalyst) and dexamethasone (Decadron) therapy for patients with previously treated relapsed or refractory (r/r) multiple myeloma (MM). The data showed that adding daratumumab to pomalidomide and dexamethasone regimen reduced the risk of...
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In a nutshell This article looked at the effectiveness and safety of continuous ixazomib (Ninlaro), thalidomide (Thalomid), and dexamethasone (Decadron) (ITd) in the treatment of relapsed and/or refractory (RR) multiple myeloma (MM). The authors found that this regimen was well tolerated and showed promising effectiveness in the treatment of...
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In a nutshell This study aimed to investigate the effectiveness and safety of combining pembrolizumab (PEM; Keytruda)) and ipilimumab (IPI; Yervoy) for the treatment of advanced-stage melanoma in patients that have progressed after previous PD-1/L1 therapy. The study concluded that this combination was well tolerated and improved the...
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In a nutshell This study evaluated the safety and effectiveness of loncastuximab tesirine (Zynlonta) for patients with diffuse large B-cell lymphoma (DLBCL) that returned or stopped responding to treatment. This study concluded that this treatment was safe and effective for these patients. Some background DLBCL is one of the most common types of...
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In a nutshell This study evaluated the outcomes of cotadutide (MEDI0382) treatment in patients with type 2 diabetes (T2D) and obesity. This study concluded that cotadutide treatment improved glycemic (blood sugar) control and weight loss in these patients. Some background T2D is commonly associated with obesity. About 70% of patients with T2D...
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In a nutshell This study evaluated the safety and effectiveness of lenalidomide (Revlimid) plus rituximab (Rituxan) for patients with diffuse large B-cell lymphoma (DLBCL) that came back or stopped responding to treatment. This study concluded that this treatment showed some effectiveness, but adding other agents may improve outcomes for these...
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In a nutshell This study looked at 8 glucagon-like peptide-1 receptor agonists (GLP-1RAs) for the treatment of type 2 diabetes (T2D). They found that all 8 were more effective than placebo and there were no significant differences in safety. Some background GLP-1RA is a type of diabetic medication that works by increasing natural...
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In a nutshell This study analyzed the effectiveness of pioglitazone (Actos) in patients with prediabetes or type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). The authors concluded that pioglitazone can significantly improve liver function in these patients. Some background NAFLD is the accumulation of fat cells in the...
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