In a nutshell This study evaluated the long-term outcomes of stereotactic ablative radiation therapy (SABR) and video-assisted thoracic surgery (VATS) for the treatment of patients with early-stage non-small cell lung cancer (NSCLC). The data showed that both SABR and VATS led to similar long-term survival outcomes. Some background...
Read MoreEvaluating the safety and effectiveness of trastuzumab deruxtecan in HER2-mutant non–small-cell lung cancer.
In a nutshell This study evaluated the effectiveness and safety of trastuzumab deruxtecan (Enhertu) in patients with previously untreated metastatic HER2-mutant non-small-cell lung cancer (NSCLC). The data showed that trastuzumab deruxtecan was safe and showed strong anticancer activity in these patients. Some background NSCLC is the most common form...
Read MoreReviewing the surgical management of benign prostatic hyperplasia
In a nutshell This study reviewed the surgical management of benign prostatic hyperplasia (BPH). Some background Benign prostatic hyperplasia (BPH) is a condition in which the prostate grows larger than normal. The prostate can then squeeze the urethra (the tube that drains the bladder) causing problems with urination. Medical...
Read MoreDoes tebentafusp provide survival benefit in patients with advanced uveal melanoma?
In a nutshell The study aimed to investigate the safety and effectiveness of immunotherapy drug tebentafusp in previously untreated advanced uveal melanoma. The study showed that tebentafusp is effective and improved the overall survival in patients with uveal melanoma. Some background Melanoma is an aggressive kind of skin cancer. Uveal melanoma...
Read MoreComparing the effectiveness and safety of nivolumab plus ipilimumab with chemotherapy versus pembrolizumab plus chemotherapy as first-Line treatment for metastatic NSCLC.
In a nutshell This study compared the effectiveness and safety outcomes of nivolumab (N; Opdivo) plus ipilimumab (I; Yervoy) with chemotherapy versus pembrolizumab (Pem; Keytruda) plus chemotherapy as first-line treatment in patients with metastatic non-small cell lung cancer (NSCLC). The data showed that N-I plus chemotherapy provided similar overall...
Read MoreHow effective is the Altis® single-incision sling procedure for stress urinary incontinence in the long-term?
In a nutshell This study evaluated the long-term effectiveness and complication rates of the Altis® sling (Coloplast) use in women with predominant stress urinary incontinence (SUI). The data showed favorable results for long-term safety and effectiveness, and improved quality of life (QoL) in these patients. Some background SUI is a common...
Read MoreDo gliflozins or gliptins improve metabolic risk in patients with type 2 diabetes?
In a nutshell This study compared canagliflozin (Invokana) to teneligliptin (Teneria) for patients with type 2 diabetes (T2D). It found that canagliflozin led to greater improvement in body weight and metabolic outcomes in these patients. Some background T2D is a health condition of the metabolism. T2D prevents the body from responding well to the...
Read MoreEvaluating kidney and heart benefits of SGLT2 inhibitors for patients with diabetes and kidney disease
In a nutshell This review looked at SGLT2 inhibitor medications for people with both type 2 diabetes (T2D) and chronic kidney disease (CKD). It found that SGLT2 inhibitors reduced worsening of the kidneys for these patients. Some background For people with diabetes, the body cannot control the amount of glucose (sugar) in the blood without treatment....
Read MoreCan pomalidomide improve multiple myeloma treatment?
In a nutshell This study looked at pomalidomide (Pomalyst) for patients with multiple myeloma (MM) which had returned after previous treatment. It found that adding pomalidomide to Vd (bortezomib, dexamethasone) led to better outcomes than Vd alone. Some background MM is a blood cancer in adults. Myeloma cells are cancerous versions of plasma cells,...
Read MoreHow does all-trans retinoic acid and arsenic trioxide treatment affect the long-term quality of life of patients with acute promyelocytic leukemia?
In a nutshell This study assessed the treatment effects of all-trans retinoic acid (ATRA; Vesanoid) and arsenic trioxide (ATO; Trisenox), compared to ATRA with standard chemotherapy on long-term health-related quality of life (HRQoL) in patients with acute promyelocytic leukemia (APL). The data showed better long-term HRQoL measures in patients treated...
Read MoreIs pyrotinib effective as a second-line treatment in patients with HER2-positive breast cancer in a real-world setting?
In a nutshell The authors evaluated the efficacy and safety of pyrotinib (Irene), for the treatment of HER2- positive metastatic breast cancer (MBC) in a real-world setting. The authors observed that pyrotinib was effective and well tolerated by patients. Some background Breast cancer (BC) is the most common tumor in women...
Read MoreEvaluating long-term safety and effectiveness of CT-P10 for the treatment of advanced follicular lymphoma
In a nutshell This study aims to investigate the long-term effectiveness and safety of the rituximab biosimilar CT-P10 (Truxima) in combination with cyclophosphamide (Cytoxan), vincristine (Oncovin), and prednisone (Deltasone) (CVP) compared with rituximab (Rituxan) for the treatment of advanced-stage follicular lymphoma (FL). The...
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