In a nutshell This study evaluated the effectiveness and safety of zanubrutinib (Brukinsa) versus ibrutinib (Imbruvica) in patients with Waldenström Macroglobulinemia (WM). The data showed that zanubrutinib had higher long-term response rates and lower side effects than ibrutinib in these patients. Some background WM is a type of cancer in which...
Read MoreEvaluating the effectiveness of lenalidomide-containing triplet regimens in patients with first relapsed multiple myeloma.
In a nutshell This study evaluated the effectiveness of lenalidomide (Revlimid)-containing regimens in patients with first relapsed multiple myeloma (MM). The data showed that daratumumab (Darzalex) combined with lenalidomide and dexamethasone (Rd) regimen significantly increased the survival without cancer worsening with fewer serious side effects...
Read MoreEvaluating the effectiveness of acupuncture for the treatment of anxiety in patients with Parkinson’s disease.
In a nutshell This study evaluated the effectiveness of acupuncture for the treatment of anxiety in patients with Parkinson’s disease (PD). The data showed that acupuncture was an effective treatment for anxiety and improved the well-being of these patients. Some background Parkinson's disease (PD) is a disorder in which part of the brain is...
Read MoreEvaluating the effectiveness and safety of gilteritinib plus azacitidine versus azacitidine alone for patients with newly diagnosed FLT3-mutated acute myeloid leukemia.
In a nutshell This study investigated the effectiveness and safety of gilteritinib (Xospata) plus azacitidine (Vidaza) versus azacitidine alone for patients with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML) who are unfit for intensive chemotherapy. The data showed that gilteritinib plus azacitidine...
Read MoreComparing the effectiveness and safety between immune checkpoint inhibitors and docetaxel in patients with non-small cell lung cancer.
In a nutshell This study compared the effectiveness and safety between immune checkpoint inhibitors (ICIs) and docetaxel (Taxotere) therapy alone in patients with non-small cell lung cancer (NSCLC). The data showed ICIs significantly improved the survival outcomes with fewer serious side effects compared to docetaxel alone for the treatment of patients...
Read MoreComparing the effectiveness and safety of intralesional verapamil and collagenase Clostridium histolyticum injections in men with Peyronie’s disease.
In a nutshell This study compared the effectiveness and safety of intralesional verapamil (Calan; ILV) and collagenase Clostridium histolyticum (Xiaflex; CCH) injections in men with Peyronie’s disease (PD). The data showed that CCH therapy was more effective than ILV, with a higher high level of patient satisfaction rate in the short term...
Read MoreEvaluating the effectiveness and safety of noninvasive cerebellar stimulation in improving the balance and walking function of patients with stroke.
In a nutshell This study evaluated the effectiveness and safety of noninvasive cerebellar stimulation (NICS) in improving the balance and walking function of patients with stroke. The data showed that NICS improved the balance and walking function in these patients. Some background A stroke is caused by a reduction in blood flow to the...
Read MoreEvaluating the effectiveness of water therapeutic exercise in breast cancer survivors
In a nutshell The study evaluated the effectiveness of aquatic therapeutic exercise in breast cancer survivors for improving symptoms and quality of life. The study found that aquatic therapeutic exercise effectively improved fatigue, pain, and quality of life in these patients. Some background Breast cancer (BC) is the most common...
Read MoreCan eye tumors be surgically removed without removing the entire eye?
In a nutshell This study looked at the effectiveness of a surgical treatment called partial transscleral sclerouvectomy (PTSU) combined with microinvasive vitrectomy and reconstruction of the eyeball (MIVR) for the treatment of tumors within the eyeball. This showed that this treatment can be effective for most eye tumors. Some background Melanoma is...
Read MoreSafety and effectiveness of two different doses of daily-administered ABX464 in patients with unresponsive rheumatoid arthritis.
In a nutshell This study investigated the safety and effectiveness of ABX464 (Obefazimod) in patients with active rheumatoid arthritis (RA) with inadequate responses to methotrexate (Trexall) or anti-tumor necrosis factor alpha (anti-TNFα) treatment. The authors concluded that ABX464 was safe and well-tolerated with promising effectiveness in these...
Read MoreEvaluating the effectiveness and safety of replacing lenalidomide with pomalidomide for the treatment of patients with multiple myeloma who are unresponsive to a lenalidomide-containing combination regimen.
In a nutshell This study evaluated the effectiveness and safety of replacing lenalidomide (Revlimid) with pomalidomide (Pomalyst) for the treatment of patients with relapsed or refractory (r/r) multiple myeloma (MM) who were unresponsive to a lenalidomide-containing combination regimen. The data showed that pomalidomide was a safe and effective...
Read MoreEvaluating the effectiveness and safety of penpulimab in patients with relapsed or refractory classical Hodgkin lymphoma.
In a nutshell This study evaluated the effectiveness and safety of penpulimab (AK105) for the treatment of patients with relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). The data showed that penpulimab was effective and safe with manageable side effects in these patients. Some background Classical Hodgkin lymphoma (cHL) is a cancer of...
Read More