In a nutshell This study investigated the short-term functional measures and complications for high-intensity focused ultrasound (HIFU) treatment in half of the prostate gland (hemi-gland) for patients with prostate cancer (PCa). The study showed that hemi-gland HIFU is a low-risk surgery and provides maintenance of sexual and urinary...
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In a nutshell The study evaluated outcomes of combining ofatumumab (Arzerra) with hyper-CVAD chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukemia (B-ALL). The authors found that the combination was safe and effective in such patients. Some background Philadelphia chromosome (Ph) is a...
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In a nutshell The study evaluated outcomes of brigatinib (Alunbrig) versus crizotinib (Xalkori) in patients with non-small cell lung carcinoma (NSCLC) and anaplastic lymphoma kinase (ALK) mutations, who were previously not treated with ALK inhibitors (ALKI). The main finding was that brigatinib had better long-term outcomes compared to crizotinib in such...
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In a nutshell This study aimed to investigate the effects of a single injection of collagenase Clostridium histolyticum (CCH; Xiapex) in early-stage Peyronie's disease (PD). The results suggested that this treatment may improve the symptoms associated with the disease. Some background Peyronie's disease (PD) is a noncancerous condition...
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In a nutshell The study investigated whether chemotherapy after surgery with or without docetaxel (Taxotere) has different outcomes in patients with different body mass indexes (BMI; a measurement of body weight in relation to height) and early breast cancer (BC). The main finding was that patients responded differently to docetaxel based on...
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In a nutshell This study looked at axicabtagene ciloleucel (Yescarta) to treat B-cell non-Hodgkin lymphoma which has returned after previous treatment outside of clinical trials. It found that most patients responded to this immune therapy and that some patients had a complete response. Some background B-cell non-Hodgkin lymphomas (NHL) are a group of...
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In a nutshell This study aimed to investigate the long-term effects of prostatic artery embolization (PAE) in benign prostatic hyperplasia. The main finding was that PAE was a safe and effective long-term treatment. Some background Benign prostatic hyperplasia (BPH) is a non-cancerous condition in which the prostate gland is larger than usual....
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In a nutshell The study evaluated long-term outcomes of combining hypofractionated intensity-modulated radiation therapy (H-IMRT) with prone-positioning in patients after conservation surgery for breast cancer. The authors found that this combination safely controlled cancer locally without affecting regional lymph nodes. Some background Adjuvant...
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In a nutshell The study monitored the occurrence of possible immune-related side effects (irSEs) in patients with advanced melanoma under single and combination therapy of ipilimumab (I; Yervoy), nivolumab (N; Opdivo), and pembrolizumab (P; Keytruda). The authors found that combination therapy increases the frequency of irSEs. Some background...
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In a nutshell The study evaluated the occurrence of differentiation syndrome (DS) in patients with IDH-mutated acute myeloid leukemia (AML) under ivosidenib (Tibsovo) and enasidenib (Idhifa) therapy. The authors found that DS is a common and adverse condition in such patients. Some background Mutations or changes in the isocitrate dehydrogenase (IDH)...
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In a nutshell This study reviewed the effect of diet on nocturia (waking up at night to urinate) severity. Some background Nocturia is among the most common and bothersome urinary symptoms. It increases with age and is associated with mortality due to its effects on sleep and daytime activity. It also increases the risk of falls and...
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In a nutshell This paper reviewed the outcomes of patients with non-responsive overactive bladder (OAB) who were treated with sacral neuromodulation (SNM) after onabotulinumtoxinA (BTX, Botox) therapy. The main finding was SNM may be successful for treating non-responsive OAB. Some background OAB is characterized by having a strong urge to...
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