In a nutshell This article analyzed the safety and effectiveness of an immunotherapy (IT) and radiotherapy (RT) combination to treat patients with non-small cell lung cancer (NSCLC). The authors found that combination therapy using an immunotherapy drug such as PD-1/PD-L1 inhibitors and RT may improve the outcomes of these patients. Some background...
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In a nutshell This study investigated the effects of surgery in patients with Peyronie's disease previously treated with Collagenase Clostridium histolyticum (CCH; Xiaflex). The main finding was that surgical treatments may improve persistent penis curvature (PC) in these patients. Some background Peyronie's disease is caused by the...
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In a nutshell This study aimed to compare the effects of prostatic urethral lift (PUL) and medical treatment on sexual function in men with benign prostatic hyperplasia (BPH). The main finding was that PUL was more effective at preserving sexual health in these men. Some background BPH is an enlarged prostate gland. BPH commonly causes lower urinary...
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In a nutshell This study compared the use of chemotherapy and bevacizumab (Avastin) or panitumumab (Vectibix) for the treatment of left-sided metastatic colorectal cancer (mCRC) without BRAF/RAS mutations (permanent changes in genes). The study found that both treatment options are effective for these patients. Some background Patients who...
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In a nutshell This study examined the effects of abiraterone acetate (AA; Zytiga) in combination with androgen deprivation therapy (ADT) for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The data showed that AA and ADT combination improves the outcomes in these patients. Some background Patients with mHSPC have...
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In a nutshell The study summarized the outcomes of bisphosphonates and RANKL-inhibitors as supportive treatment in men with prostate cancer (PC) and bone metastases (BM). The authors recommended that a balance between the efficacy and safety of such therapies must be considered for preventing skeletal events in such patients. Some background Men whose...
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In a nutshell The study evaluated outcomes of tandem autologous stem cell transplantation (ASCT) – reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) in patients with high-risk (HR) relapsed Hodgkin lymphoma (HL). The main finding was that this approach was safe and effective in such patients. Some...
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In a nutshell This study aimed to investigate the combination of bendamustine (Treanda), ofatumumab (Arzerra), carboplatin (Paraplatin), and etoposide (Etopophos) in patients with relapsed/refractory aggressive non-Hodgkin lymphoma (NHL). This study concluded that this combination was safe and effective in these...
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In a nutshell The study analyzed outcomes of high-dose therapy (HDT) with autologous hematopoietic stem cell transplantation (AHSCT) for patients with non-Hodgkin lymphoma (NHL) in a resource-limited country and evaluated whether upfront AHSCT could be an effective treatment. The authors found promising outcomes of this treatment in a resource-limited...
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In a nutshell This study aimed to investigate the safety and effectiveness of the combination of ivosidenib (Tibsovo) and azacitidine (Vidaza) in patients with acute myeloid leukemia (AML) with isocitrate dehydrogenase 1 (IDH1) mutation (permanent change). This study concluded that this combination was well tolerated and...
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In a nutshell The study evaluated outcomes of ixazomib (Ninlaro) as a maintenance therapy in patients with newly diagnosed multiple myeloma (MM) not undergoing autologous stem cell transplantation (ASCT). The main finding was that ixazomib maintenance safely improved progression-free survival (PFS) in such patients. Some background...
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In a nutshell The study evaluated the effectiveness of DA-9701 (Motilitone) on gastrointestinal symptom-related quality of life (GIS-QoL) in patients with Parkinson’s disease (PD) who are on stable dopaminergic medications. The main finding was that DA-9701 improved GIS-QoL in such patients. Some background Gastrointestinal symptoms (GIS)...
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