In a nutshell This phase 3 trial will investigate the safety and effectiveness of switching from rituximab (Rituxan/Mabthera) to DRL_RI in patients with rheumatoid arthritis (RA). The main outcome will be the rate of side effects and anti-drug drug antibodies (ADAs). This study is recruiting at several locations in the United...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of ATI-450 in patients with rheumatoid arthritis (RA). The main outcomes will be the number of side effects and the change in disease activity (DA). This trial is recruiting at several locations in the United States. The details Rheumatoid...
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In a nutshell This study investigated tapering glucocorticoids (GCs) in rheumatoid arthritis (RA) patients who have achieved low disease activity (LDA). They found that continuing GCs at a low dose was more effective at sustaining LDA. Some background Rheumatoid arthritis (RA) is a chronic condition. Excess inflammation causes painful...
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In a nutshell This study investigated the use of low dose (LD) glucocorticoids (GC) combined with methotrexate (MTX; Otrexup) and hydroxychloroquine (HCQ; Plaquenil).in early rheumatoid arthritis (RA). They found that LD-GCs improved disease activity (DA) combined with MTX and HCQ in these patients. Some background...
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In a nutshell This study investigated if sarilumab (Kevzara) is safe and effective alone or in combination with other drugs in patients with moderate to severe rheumatoid arthritis (RA). They found that this treatment was effective and well-tolerated in these patients. Some background Rheumatoid arthritis (RA) is a chronic immune...
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In a nutshell This study investigated hearing loss (HL) in patients with rheumatoid arthritis (RA). They found that RA was associated with senorineural HL (SNHL). Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by excessive inflammation. This leads to painful swelling in the joints. This causes degeneration of...
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In a nutshell This study investigated if subcutaneous methotrexate (MTX-sc; Otrexup) is safe and well tolerated in patients with rheumatoid arthritis (RA). They found that MTX-sc is safe and well-tolerated in these patients. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by painful inflammation in...
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In a nutshell This study investigated treatment tapering strategies (TTS) in patients with rheumatoid arthritis (RA). They found that drug-free remission (DFR) can be achieved in a small number of patients. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by excessive inflammation. This leads to painful swelling in...
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In a nutshell This study investigated if garlic supplementation improves rheumatoid arthritis (RA) symptoms. They found that garlic supplementation improved RA inflammation and symptoms. Some background Rheumatoid arthritis (RA) is a chronic immune condition. It is caused by excess inflammation. It leads to painful swelling in the joints. It...
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In a nutshell This study investigated the effect of adding methotrexate (Otrexup) after adalimumab (Humira) treatment In patients with rheumatoid arthritis (RA). They found that methotrexate added to adalimumab improves disease activity (DA) in patients without previous biologic treatment. Some background Rheumatoid...
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In a nutshell This study investigated ocular (eye) conditions (OCs) in patients with rheumatoid arthritis (RA). They found that OCs affect approximately 20% of patients with RA. Some background Rheumatoid arthritis (RA) is a chronic immune condition. It is caused by painful inflammation in the joints. This leads to joint damage and disability...
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In a nutshell This study investigated if reducing the doses (tapering) of biologic drugs maintains effectiveness in patients with rheumatoid arthritis (RA). They found that drug tapering maintained low disease activity (LDA) and remission while reducing side effects and costs. Some background Rheumatoid arthritis (RA) is a chronic...
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