In a nutshell This study investigated the relationships among depression and anxiety, diet, and disease activity or physical function in patients with rheumatoid arthritis (RA). The data showed that there was a relationship between depression and lower fish intake frequency in these patients. Some background RA is a chronic inflammatory...
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In a nutshell This study looked at the safety and effectiveness of olokizumab (Artlegia) as an add-on to methotrexate (Otrexup) treatment in rheumatoid arthritis. It found the olokizumab was associated with significant improvements in RA symptoms and physical function. Some background Rheumatoid arthritis (RA) is a condition affecting...
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In a nutshell This study compared the effectiveness and safety of tofacitinib (Xeljanz) and baricitinib (Olumiant) in patients with rheumatoid arthritis in a real-world setting. The data showed that tofacitinib and baricitinib had similar effectiveness and safety but clinical responses may depend on previous use of anti-rheumatic drugs. Some...
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In a nutshell This study investigated the effectiveness and safety of rupatadine (RUP; Rupafin) and montelukast (MON; Singulair) as additive therapies for patients with rheumatoid arthritis (RA). The authors concluded that RUP and MON provided clinical and functional improvements in these patients. Some background RA is a chronic autoimmune,...
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In a nutshell This study assessed the effectiveness of bazedoxifene (Duavee) in the prevention of bone loss in patients with rheumatoid arthritis (RA) while receiving low-dose glucocorticoid (GC) treatments. The data showed improved bone mineral density (BMD) and reduced bone turnover markers (BTMs) in these patients. Some background RA is a...
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In a nutshell This study investigated the duration, level, and predictors of unacceptable pain during the early stages of rheumatoid arthritis (RA), with and without low inflammation. The authors concluded that over a 5-year period, more than one-third of patients studied had unacceptable pain that was linked to lower swollen joints. Some background...
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In a nutshell This study investigated whether switching a first-line targeted therapy (TT) within 6 months of not attaining low disease activity (LDA) enhances the chance of patients with rheumatoid arthritis (RA) achieving their target at the 12-month visit. The data showed an increased chance of achieving a target of remission or LDA at the...
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In a nutshell This study compared the benefit of two doses of filgotinib (Jyseleca) with adalimumab (Humira) and placebo, in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX; Otrexup). The data showed that filgotinib reduced RA signs, improved physical activity, prevented structural joint damage progression, and was...
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In a nutshell This study investigated the relationship between tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, and serum certolizumab pegol (CZP; Cimzia) levels in patients with rheumatoid arthritis (RA) treated with CZP. The authors concluded that CZP was highly effective in patients with low serum TNFα levels at 24 hours after...
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In a nutshell This study analyzed the effect of using biological disease-modifying anti-rheumatic drugs (bDMARDs) on fracture risk in patients with rheumatoid arthritis (RA). The data suggest no evidence that the use of bDMARDs impacts fracture risk in these patients. Some background RA is a chronic, systemic (affects the whole body) inflammatory...
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In a nutshell This study described the guidelines from the Canadian Rheumatology Association (CRA) on the use of COVID-19 vaccines in patients with autoimmune rheumatic diseases (ARDs). The CRA recommended the use of Canada-approved COVID-19 vaccines for patients with ARDs. Some background ARDs include chronic, inflammatory conditions such as...
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In a nutshell This study reviewed the effectiveness of resistance exercise in patients with rheumatoid arthritis (RA). The data showed that resistance exercise can significantly improve disease activity in these patients. Some background RA is a progressive, autoimmune, inflammatory disease that affects multiple joints in the body. RA activity is...
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