In a nutshell This study assessed whether subcutaneous (SC) methotrexate (MTX) was effective in rheumatoid arthritis (RA) patients who suffered side effects from oral MTX, or where oral MTX was ineffective. The study concluded that SC MTX injections were effective and very well tolerated. Some background RA is a chronic autoimmune disease (when...
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In a nutshell This study investigated the effectiveness of combined ultrasound for assessing synovitis in rheumatoid arthritis (RA) patients starting abatacept (Orencia) with methotrexate (Trexall). The study concluded that the ultrasound technique and the drug combination were effective. Some background RA is a chronic autoimmune disease...
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In a nutshell This study assessed the risks of rheumatoid arthritis (RA) patients developing chronic kidney disease (CKD) and glomerulonephritis (GN), and subsequently developing cardiovascular (CV) complications. The study concluded that there was an increased risk of CKD and GN in RA patients, and an increased risk of CV complications in patients...
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In a nutshell This study assessed the safety and effectiveness of tocilizumab (TCZ, Actemra) in patients with systemic juvenile idiopathic arthritis (sJIA). The study concluded that TCZ was safe and effective. Some background Arthritis causes pain, stiffness, swelling and restricted movement in the joints. sJIA is a severe form of arthritis that...
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In a nutshell This study looked at the effectiveness of tocilizumab (TCZ, Actemra) in patients with early rheumatoid arthritis (RA). The study concluded that TCZ is effective both on its own and combined with another drug, methotrexate (MTX, Trexall) in treating patients with RA. Some background Rheumatoid arthritis is a chronic autoimmune (the...
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In a nutshell This study examined the effectiveness of peficitinib in patients with moderate to severe rheumatoid arthritis. The results showed that this new drug was safe and effective. Some background Rheumatoid arthritis (RA) is a chronic autoimmune disease (when the immune system attacks healthy tissue) that causes pain,...
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In a nutshell This study looked at the effects of maternal and paternal exposure to the drug abatacept (Orencia). Based on the data, there were no increased instances of birth abnormalities. Some background Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes inflammation of the joints. Medications used to treat...
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In a nutshell The authors evaluated the effect of abatacept (Orencia) plus methotrexate (Trexall) in reducing the symptoms (remission) of early rheumatoid arthritis. Some background In rheumatoid arthritis (RA), the immune system begins attacking healthy tissues the way it normally attacks viruses or bacteria. This can cause inflammation,...
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In a nutshell This study examined stopping methotrexate after 6 months of combined treatment with etanercept. Results showed that continuing combination treatment is preferable to stopping methotrexate. Some background For patients with rheumatoid arthritis, a combination of treatments is often more effective than a single treatment....
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In a nutshell The authors reviewed current treatment options for the treatment of polyarticular juvenile idiopathic arthritis (pJIA). Some background JIA is the most common form of arthritis in children under the age of 16. In pJIA, more than 6 joints are involved in the first 6 months of the disease. Recent studies have shown that pJIA patients...
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In a nutshell The aim of this study was to investigate the effectiveness of cetrorelix in rheumatoid arthritis (RA) patients with high gonadotropin hormone levels. Some background Gonadotropin-releasing hormone (GnRH) is a combination of several hormones that are responsible for regulating normal growth, sexual development and reproductive...
Read MoreIn a nutshell This study, recruiting in Boston, Massachusetts, will evaluate several parameters in rheumatoid arthritis (RA) patients based on observation. The primary outcomes to be investigated are the biomarkers that predict drug response and side effects in RA. The details In RA, the immune system begins attacking healthy tissues the way...
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