In a nutshell This study investigated the cost-effectiveness of different approaches to treat rheumatoid arthritis. They found that csDMARDs are as effective as TNF inhibitors and cost less. Some background Treating rheumatoid arthritis (RA) involves reducing inflammation. Inflammation leads to painful swelling and joint damage....
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In a nutshell This study investigated if hydroxychloroquine (HCQ; Plaquenil) is an effective treatment in rheumatoid arthritis (RA). They found that combining HCQ with other RA drugs improves symptoms. Some background Rheumatoid arthritis (RA) is a long-term condition. It is caused by excessive inflammation in the joints. This leads to painful...
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In a nutshell This study investigated the mortality rates in patients with early rheumatoid arthritis (RA). They found that mortality rates were similar to the general population in these patients. Some background Rheumatoid arthritis (RA) is a long-term condition. It causes painful inflammation in the joints. To treat RA, patients take...
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In a nutshell This study investigated if behavioral therapy improves fatigue in rheumatoid arthritis (RA). They found that behavioral therapy reduced fatigue in patients with RA. Some background Rheumatoid arthritis (RA) is a long-term condition caused by inflammation. It leads to painful swelling in the joints and disability. Fatigue (tiredness)...
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In a nutshell This study investigated the safety of tofacitinib (TFB; Xeljanz) in the treatment of rheumatoid arthritis (RA). They found that patients taking TFB alone had a reduced risk of infections. Some background Rheumatoid arthritis (RA) is a chronic condition caused by inflammation. This leads to painful swelling in the joints and...
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In a nutshell This phase 1/2a trial will investigate the safety of an autologous mesenchymal stem cell transplant (AMSCT) to treat rheumatoid arthritis (RA). The main outcome measured will be the safety of AMSCT and response after 1 year. This trial is recruiting in Texas, United States. The details Rheumatoid arthritis (RA) is a chronic...
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In a nutshell This study investigated if water-based exercise (WBE) improved exercise capacities (ECs) in juvenile idiopathic arthritis (JIA). They found that anaerobic exercise capacity (AnEC) was improved in patients with JIA. Some background Juvenile idiopathic arthritis (JIA) is a condition that affects children under the age of...
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In a nutshell This study investigated if biomarkers (BMs) can predict the response to methotrexate (MTX) in early rheumatoid arthritis (RA). They found that the level of BMs at baseline could predict the success of MTX treatment. Some background Rheumatoid arthritis (RA) is a condition caused by inflammation. This leads to painful swelling...
Read MoreIn a nutshell This study investigated if a treat-to-target (TTT) approach reduces cardiovascular disease (CVD) risk in patients with rheumatoid arthritis (RA). They found that TTT reduced CVD risk in patients with RA over 5 years. Some background Rheumatoid arthritis (RA) is a chronic condition caused by inflammation. Patients with RA have...
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In a nutshell This study investigated if tumor necrosis factor inhibitors (TNFi) are effective as a first-line treatment of rheumatoid arthritis (RA). They found that patients treated first with TNFi had greater improvements in RA symptoms. Some background Rheumatoid arthritis (RA) is a chronic disease. It is caused by inflammation...
Read MoreIn a nutshell This study investigated disease activity in patients with rheumatoid arthritis (RA) by season. They found that disease activity was lowest in fall and highest in spring. Some background Rheumatoid arthritis (RA) is a condition affecting the joints of the body. In RA, there is an excess of inflammation. This leads to painful swelling...
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In a nutshell This phase 1b/2a trial will investigate the safety and effectiveness of AMG 592 in rheumatoid arthritis (RA). The main outcome will be a 20% improvement in symptoms at week 12. The details Rheumatoid arthritis (RA) is a condition caused by long-term inflammation. This leads to painful swelling in the joints. To treat RA, drugs that...
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