In a nutshell The study compared the effectiveness of bicalutamide (Casodex) to enzalutamide (Xtandi), both in combination with androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC). The comparison showed that enzalutamide with ADT improves the outcomes particularly in Black men with mHSPC. Some...
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In a nutshell This study compared the patient-reported quality of life outcomes between conventionally fractionated radiation treatment (CFRT) and ultra-hypofractionated radiation treatment (UHFRT) in patients with localized prostate cancer. The data showed that both radiotherapy techniques led to similar long-term outcomes. Some background Radiation...
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In a nutshell This study reported the long-term effectiveness and quality of life outcomes after prostate cryoablation (a process that uses extreme cold to destroy prostate tumor) treatment for patients with low and intermediate-risk prostate cancer (PCa). The data showed that the treatment had good outcomes with minimal impact on urinary and sexual...
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In a nutshell This study investigated the effectiveness and safety of stereotactic ablative radiation therapy (SABR) in the treatment of patients with oligometastatic (few metastases) cancer. The data showed that the use of SABR in these patients was associated with high overall survival and low toxicity. Some background Oligometastatic cancer (OMC)...
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In a nutshell This study evaluated the long-term outcomes of patients who underwent whole-gland high-intensity focused ultrasound (HIFU) for non-metastatic prostate cancer. The data showed that HIFU has favorable outcomes in low- and intermediate-risk groups of patients. Some background HIFU is a treatment option for prostate...
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In a nutshell This study examined whether anxiety and depression (AD) can worsen life quality after patients underwent radical prostatectomy (RP; removal of the prostate), as a treatment for prostate cancer. The authors found that patients with AD were more likely to experience urinary incontinence (UI; involuntary urine leakage) and...
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In a nutshell This clinical trial is evaluating the safety and effectiveness of an experimental treatment, BXCL701, in combination with pembrolizumab (Keytruda) for people with small cell neuroendocrine prostate cancer (SCNPCa). The main outcome to be measured will be the response rate to the study treatment. The details Prostate cancer is the...
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In a nutshell This study compared the surgical outcomes of patients undergoing single-port extraperitoneal prostatectomy (SP-EPP) with conventional multiport transperitoneal robot-assisted radical prostatectomy (MP-RARP). The data showed that the SP-EPP approach was associated with a shorter length of hospital stay as well as a reduction in pain...
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In a nutshell This study investigated the relationship between radiation doses in prostate brachytherapy (BT) and erectile function reduction in patients with localized prostate cancer (PCa). The data showed that sexual function decreased over time with higher doses of BT. Some background Localized prostate cancer (PCa) is a form of cancer that...
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In a nutshell This trial is aiming to examine the safety and effectiveness of experimental treatment DF6002 alone or in combination with nivolumab (Opdivo) in the treatment of advanced solid tumors, including prostate cancer. The main outcomes to be measured are drug toxicity and the response rate of patients to the drug. This trial is being carried out...
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In a nutshell This study explored the outcomes of statin (cholesterol-lowering drugs) treatment in patients with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). The authors found that the combination of statins and ADT improved the outcomes of these patients and intermittent ADT (IADT) increased the time...
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In a nutshell The study examined whether delaying prostate surgery affected the outcomes of patients with high-risk localized prostate cancer. The authors found that the procedure could be safely delayed in these patients for up to 6 months after initial diagnosis without higher risks of adverse outcomes. Some background Radical prostatectomy...
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