In a nutshell This trial is examining the effectiveness of radiation therapy with or without apalutamide (Erleada) in the treatment of stage 3-4 prostate cancer. The main outcome to be measured will be survival without cancer worsening. This trial is recruiting in Canada and the United States. The details Radiation therapy uses high energy x-ray...
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Evaluating a radionuclide treatment for metastatic castration-resistant prostate cancer
In a nutshell This study investigated the effectiveness of a radionuclide (RN), [¹??Lu]-PSMA-617, to treat metastatic castration-resistant prostate cancer (mCRPC) that has worsened after standard treatments. They found that this treatment was safe and effective for these patients. Some background Prostate cancer (PC) affects the...
Read MoreHow long should hormonal therapy continue in patients who have received postprostatectomy radiotherapy?
In a nutshell This study examined how long hormonal therapy should continue in patients who have received radiotherapy after prostate removal surgery (prostatectomy). This study concluded that patients with a higher number of risk risk factors should receive HT for a longer period of time. Some background Radical prostatectomy (RP) is...
Read MoreLooking for patients with prostate cancer to test a vaccine
In a nutshell This phase 2 trial will investigate the safety and effectiveness of a prostate cancer vaccine. The main outcome will be the rate of prostate cancer progression. The details Prostate cancer (PC) is cancer the originates in the prostate gland (PG). PC is very common, however, most men will recover from it. The progression of PC is...
Read MoreIs single fraction high dose brachytherapy for prostate cancer safe and effective?
In a nutshell This study examined if single fraction, high dose brachytherapy for low and medium risk prostate cancer is safe and effective. This study concluded that this treatment for prostate cancer is safe and effective, however, it should not be used outside of clinical trials. Some background Prostate cancer can be treated using...
Read MoreSearching for patients with advanced prostate cancer to test a new drug combination
In a nutshell This phase 3 trial will evaluate the safety and effectiveness of olaparib (Lynparza) and abiraterone (Zytiga) combination in prostate cancer. The main outcome will be the rate of survival without cancer growing or spreading. The details Prostate cancer (PC) is cancer that originates in the prostate gland. When cancer progresses to a...
Read MoreComparing urinary function after robotic surgery or radical perineal surgery for early stage prostate cancer
In a nutshell This study aimed to evaluate two less invasive surgeries in the treatment of localized prostate cancer (PCa). This study found that there was no difference in urinary symptoms 12 months after the two methods. Some background Prostate surgery is a treatment option for prostate cancer (PCa). This surgery can be carried out by classic...
Read MoreHigh intensity focused ultrasound for primary localized prostate cancer.
In a nutshell This study aimed to investigate how effective high-intensity focused ultrasound (HIFU) is in the treatment of prostate cancer (PCa). This study found that HIFU is an effective option to treat PCa. Some background HIFU (high intensity focused ultrasound; Sonablate 500) is a treatment option for prostate cancer...
Read MoreTime to lowest PSA level and the risk of death from prostate cancer
In a nutshell This study aimed to investigate the link between PSA (prostate-specific antigen) levels and prostate cancer (PCa) prognosis. This study found that a lower PSA level (less than 0.2ng/ml) was associated with less risk of dying from PCa. Some background The PSA is a substance produced by the prostate. It can be used as a marker during...
Read MoreCombined radiation therapy used to treat unfavorable-risk prostate cancer
In a nutshell This study aimed to investigate the use of combined-modality radiation treatment (CRT) in the treatment of prostate cancer (PCa). This study found that CRT is an effective treatment for PCa. Some background Radiation therapy can be delivered externally such as external beam radiation therapy (EBRT), or directly into the...
Read MoreLooking for men with castration-resistant prostate cancer to try 177Lu-PSMA-617
In a nutshell This trial is looking at the effectiveness of 177Lu-PSMA-617 in the treatment of castration-resistant (tumor grows even with hormone therapy) prostate cancer. The main outcome to be measured is overall survival. The details Prostate cancer is an uncontrolled growth of the cells which make up the prostate gland. Prostate...
Read MoreLooking for men with prostate cancer to test chemotherapy in combination with radiotherapy
In a nutshell This trial evaluates the effectiveness of using chemotherapy in combination with radium-223 (a type of internal radiotherapy). The main outcome to be measured is overall survival. This trial is taking place in the United States. The details Prostate cancer is an uncontrolled growth of the cells which make up the prostate gland. Prostate...
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