In a nutshell This article investigated the safety and effectiveness of ixazomib (Ninlaro), melphalan (Alkeran), and prednisone (Deltasone) followed by maintenance (treatment meant to keep cancer from coming back) ixazomib for patients with multiple myeloma. The authors concluded that this...
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In a nutshell This article investigated the safety and effectiveness of combining ixazomib (Ninlaro), cyclophosphamide (Cytoxan) and dexamethasone (Decadron) for the treatment of relapsed or refractory (does not respond to treatment) multiple myeloma (RRMM). The authors concluded that the combination treatment is safe and gave...
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In a nutshell This article investigated the safety and effectiveness of adding daratumumab (Darzalex) to lenalidomide (Revlimid) and dexamethasone (Decadron) for the treatment of relapsed or refractory (does not respond to treatment) multiple myeloma (RRMM). The authors concluded that the addition of daratumumab is safe and...
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In a nutshell This article investigated the safety and effectiveness of subcutaneous (under the skin) injection at home of bortezomib (Velcade) in elderly and frail patients on the bortezomib–melphalan–prednisone (VMP) regimen. The authors concluded that domestic injection of bortezomib is safe and can...
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In a nutshell This article investigated the safety and effectiveness of high-dose therapy with autologous stem cell transplantation (HDT-ASCT) and maintenance treatment (treatment meant to keep cancer from coming back) with lenalidomide (Revlimid) for patients with multiple myeloma. The authors concluded that this therapy is safe...
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In a nutshell This article investigated the safety and effectiveness of adding daratumumab (Darzalex) to bortezomib (Velcade) and dexamethasone (Decadron) for the treatment of relapsed or refractory (does not respond to treatment) multiple myeloma (RRMM). The authors concluded that the addition of daratumumab is safe and gave the greatest benefit to...
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In a nutshell This study investigated the effects of adding elotuzumab to lenalidomide and dexamethasone to treat un-responsive multiple myeloma. The main finding was that patients treated with elotuzumab responded better to lenalidomide and dexamethasone. Some background Many patients respond well to treatment for multiple myeloma (MM). However some...
Read MoreIn a nutshell This study aimed to compare the long-term effects of thalidomide (Immunoprin) to those of classic anti-cancer drugs in patients with recently diagnosed multiple myeloma. Thalidomide appeared effective but many patients experienced side-effects that affected treatment. Some background Vincristine (Oncovin), doxorubicin...
Read MoreIn a nutshell This study investigated the effects of stem cell transplant and anti-cancer drug treatment for Multiple Myeloma. Stem cell transplant appeared to increase survival in patients with Multiple Myeloma. Some background Multiple myeloma (MM) is a type of cancer in which red blood cells over produce antibodies. Stem cell transplant is a common...
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In a nutshell This paper compared the safety and effectiveness of elotuzumab (Empliciti) plus lenalidomide (Revlimid) and dexamethasone (Decadron) with lenalidomide and dexamethasone in unresponsive multiple myeloma. It was found that elotuzumab plus lenalidomide and dexamethasone was more effective than lenalidomide and dexamethasone alone. Some...
Read MoreIn a nutshell This study investigated the effects of lenalidomide/dexamethasone (Revlimid/Dexasone) combination treatment in relapsed multiple myeloma. The main finding was that the type of relapse may predict how a patient responds to lenalidomide/dexamethasone treatment. Some background Common treatments for multiple myeloma (MM) include...
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In a nutshell This study investigated the outcomes of hemodialysis in patients with multiple myeloma. The main finding was that those who did not undergo hemodialysis had better survival than those who did. Some background Multiple myeloma (MM) is a type of cancer which affects the white blood cells which produce antibodies (proteins that fight...
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