In a nutshell This study evaluated how effective regular scanning is in identifying metastatic recurrence in patients with stage III melanoma that was surgically removed. Results showed that scanning every 6 or 12 months was reasonably good at detecting metastatic recurrence. Some background Melanoma is a form of aggressive skin cancer. Treatment...
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In a nutshell This study investigated the effectiveness and safety of stereotactic ablative radiation therapy (SABR) in the treatment of patients with oligometastatic (few metastases) cancer. The data showed that the use of SABR in these patients was associated with high overall survival and low toxicity. Some background Oligometastatic cancer (OMC)...
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In a nutshell This study evaluated the impact of radiotherapy (RT) on controlling brain metastasis (BM). The study suggested that a single dose of RT was effective in controlling small BM. Larger BM could be controlled more effectively with multiple rounds of RT. Some background The spread of cancer from the original tumor to other parts of the...
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In a nutshell This study compared how safe and effective are different therapies after surgery in patients with melanoma. This study showed that nivolumab had the best outcome for patients with melanoma following surgery. Some background Melanoma is a type of skin cancer. First line therapy for melanoma involves surgery to...
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In a nutshell The aim of this study was to evaluate the safety of giving stereotactic radiosurgery (SRS) at the same time as other cancer treatments for patients who have brain metastasis. The study found that SRS given in combination with chemotherapy, immunotherapy, or targeted therapy was safe with low levels of side effects. Some background...
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In a nutshell This trial is aiming to examine the safety and effectiveness of experimental treatment DF6002 alone or in combination with nivolumab (Opdivo) in the treatment of advanced solid tumors, including melanoma. The main outcomes to be measured are drug toxicity, and response rate of patients to the drug. This trial is being...
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In a nutshell This study examined the safety and effectiveness of gamma knife radiosurgery for the treatment of eye melanomas. It found that this treatment modality is effective for achieving local control in these patients. Some background Gamma knife radiosurgery is a treatment that involves focussing a beam of radiation on a tumor to...
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In a nutshell The aim of this study was to check the safety and effectiveness of the combination of ipilimumab (Yervoy) and radiotherapy (RT) in patients with high-risk melanoma. The study found that ipilimumab + RT was safe and had good responses in these patients. Some background Melanoma is a type of skin cancer. First line therapy for...
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In a nutshell This study evaluated the risk of heart-related (HR) side effects in patients with melanoma treated with immune checkpoint inhibitors (ICI). Patients with melanoma were shown to have a higher risk of developing HR side effects when treated with ICIs. Some background ICIs are a type of cancer therapy used to treat a wide variety...
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In a nutshell The study evaluated the timing of radiotherapy (RT) and immune-checkpoint therapy (ICT) on the outcomes of patients with brain metastasis (BrM) resulting from melanoma and non-small cell lung cancer (NSCLC). The authors found that RT and ICT given at the same time may improve response and delay recurrence in these patients. Some...
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In a nutshell This study looked at the effectiveness of immune therapy in patients aged over 65 with advanced melanoma. They found that immune therapy led to longer survival times than other treatments such as chemotherapy. Some background Immune therapy has improved the outlook for patients with advanced skin melanoma. These medications...
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In a nutshell This trial is being carried out to assess the safety and effectiveness of an experimental drug called BCA101 alone and in combination with pembrolizumab (Keytruda) in advanced solid tumors that are EGFR-positive. The main outcomes to be measured are the occurrence of side effects and response to treatment. The details Advanced...
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