In a nutshell This study investigated which patients with advanced melanoma would benefit the most from a cancer vaccine. The study found that the vaccine was most effective in patients with stage IV melanoma who has surgery to remove the tumor completed all treatment doses. Some background Melanoma is an aggressive type of skin cancer. Treatment...
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In a nutshell This study investigated the effectiveness of dabrafenib (Tafinlar) plus trametinib (Mekinist) treatment before surgery for patients with unresectable advanced-stage melanoma. The data showed that this treatment was effective before surgery and allowed for the removal of tumors. Some background Melanoma is an aggressive type of skin...
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In a nutshell This study described the updates to the National Comprehensive Cancer Network (NCCN) skin melanoma guidelines. Some background Melanoma is one of the most aggressive forms of skin cancer. Patients often have a biopsy of a suspected melanoma to evaluate the severity of the tumor. Treatment for melanoma includes surgery to remove the...
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In a nutshell The aim of this study was to investigate the long-term safety and effectiveness of pembrolizumab (Keytruda) for patients with stage III melanoma that was surgically removed. The study found that patients treated with pembrolizumab were more likely to have an improved outcome. Some background Melanoma is one of the most...
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In a nutshell This study is searching for participants with advanced solid tumors including melanoma to examine the safety and effectiveness of experimental drug avapritinib (Ayvakit). The main outcomes to be measured are the response to treatment and side effects. This trial is being conducted in Texas, US. The details Some cancers grow as a...
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In a nutshell The aim of this study was to evaluate the outcomes of combining stereotactic radiosurgery (SRS) with BRAF inhibitors for brain metastasis in patients with melanoma. The study found that adding BRAF inhibitors to STS improved patient outcomes. Some background Melanoma is one of the most aggressive forms of skin cancer....
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In a nutshell The aim of this study was to evaluate the safety and effectiveness of a cancer vaccine for patients with advanced melanoma. The study found that the vaccine was safe and increased patient survival without worsening of the disease. Some background Treatment for early-stage melanoma includes surgery to remove the tumor. For...
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In a nutshell The aim of this study was to evaluate different types of therapy after surgery for patients with high-risk melanoma. The study found that add-on targeted therapy or immunotherapy was likely to decrease the risk of disease progression in these patients. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
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In a nutshell This study evaluated the safety and effectiveness of nivolumab (Opdivo) in patients with advanced melanoma in a real-world practice. The study found that the safety and effectiveness of nivolumab in these patients were similar to that reported in clinical trials. Some background Melanoma is a form of skin cancer. In more advanced...
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In a nutshell The aim of this study was to evaluate if cell-free circulating tumor DNA (ctDNA) in the blood could predict a patient's response to targeted therapy. The study found that measuring ctDNA could predict how a patient would respond to therapy. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
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In a nutshell The aim of this study was to identify a drug that prevented the spread (metastasis) of melanoma. The study found that patients who took statins had a lower risk of developing metastasis. Some background Melanoma is a form of skin cancer. Treatment for melanoma includes surgery to remove the tumor. In more advanced melanoma, the tumor can...
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In a nutshell This study evaluated the use of immunotherapy (IT) and/or radiotherapy (RT) for the treatment of melanoma with brain metastasis (MBM). The study found that combining IT with RT improved survival outcomes for these patients. Some background The spread of cancer from the original tumor to other parts of the body is called metastasis....
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