In a nutshell The authors compared nivolumab (Opdivo) in combination with ipilimumab (Yervoy) to ipilimumab alone in the treatment of advanced melanoma. Some background In the advanced stages of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. In many melanoma...
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In a nutshell The authors reviewed the biology as well as current and future treatment options for eye melanoma. Some background Uveal melanoma is a rare cancer (melanoma) of the eye. It involves three parts of the eye (iris, ciliary body and choroid) known together as the uvea. Eye melanoma is associated with a high risk...
Read MoreIn a nutshell The authors reviewed current and future immunotherapies for the treatment of melanoma. Some background In the advanced stages of melanoma (stage III/IV), cancer spreads rapidly from the skin to other parts of the body. This is known as metastasis. Conventional cancer treatments such as radiotherapy (directs a...
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In a nutshell The authors determined the risk of disease progression in melanoma patients based on the status of sentinel lymph node (SLN). Some background Classification of skin melanoma based on SLN is the standard procedure used to determine the course of treatment in melanoma patients. SLN is the first lymph node...
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We’ve gotten used to thinking about having cancer in your colon or lung or breast. We’ve systematized treatments and research of cancer by the organ that’s affected. And we’ve been fundraising that way too–pitting lung cancer against breast cancer against childhood cancers. But what if this view of cancer is totally...
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In a nutshell The authors determined the benefit of measuring tumor cells in the blood for the treatment of advanced melanoma. Some background Treatment options for advanced melanoma include targeted therapy (targeting specific genes or proteins) and immunotherapy (using the body’s own immune system to fight cancer)....
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In a nutshell The authors analyzed the risk factors for developing brain metastasis in head and neck melanoma. Some background Head and neck melanomas occur in 15-20% of all skin melanomas. Head and neck melanoma often spread (metastasis) to the brain, resulting in poor survival time. The chance of developing brain metastasis in...
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In a nutshell The authors analyzed the effectiveness of radiotherapy after surgery in desmoplastic melanoma- a rare kind of skin cancer. Some background Desmoplastic melanoma is a rare form of skin cancer in which the cancer cells are surrounded by fibrous tissues (eg; tissues that make up ligaments, tendons or nerves). Local...
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In a nutshell The authors analyzed the effectiveness and safety of retreatment with ipilimumab (Yervoy) in patients with advanced melanoma. Some background The survival rate in advanced melanoma is poor. Ipilimumab, an immunotherapy (treatment that uses the body’s own immune system to fight cancer), is an...
Read MoreIn a nutshell The authors analyzed the factors that predict the return of melanoma (recurrence) and the survival of recurrent melanoma patients following a negative diagnostic report. Some background One of the most important factors that predict the possibility of melanoma recurrence is the status of sentinel lymph node (SLN). SLN is...
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In a nutshell The authors assessed the effectiveness of a specific radiation therapy called plaque brachytherapy in treating eye melanoma. Some background Uveal melanoma is cancer (melanoma) of the eye involving three parts of an eye (iris, ciliary body or choroid) – together known as the uvea. Chorodial melanoma is...
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In a nutshell The authors analyzed the effectiveness of different skin-directed therapies for skin metastasis from advanced cancers. Some background Skin (cutaneous) metastasis is defined as the spread of cancer cells from the primary tumor to the skin. Based on reports, it is estimated that 5.3% of all cancer patients can develop skin...
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