In a nutshell This phase 2 trial will investigate the effectiveness of drug combinations including a new drug, spartalizumab (PDR001), in advanced melanoma. The main outcome will be the overall response rate. The details Patients with advanced melanoma have limited treatment options. Surgery may not be a treatment option for many of these...
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Searching for patients with advanced melanoma to trial a new treatment
In a nutshell This phase 2 trial will investigate the effectiveness of combining relatlimab and nivolumab (Opdivo) to treat melanoma. The main outcomes will be a change in tumor size and response to treatment. This trial is recruiting in Pittsburgh, Pennsylvania, United States. The details Melanoma is a type of skin...
Read MoreInfluenza vaccination and immune-checkpoint inhibitors – what are the risks to patients with cancer?
In a nutshell This study investigated the effect of immune-checkpoint inhibitors (ICIs) on influenza vaccination in patients with cancer. They found that influenza vaccination is safe in these patients Some background Immune-checkpoint inhibitors (ICIs) are a new type of drug to treat cancer. ICIs can be effective in some advanced cancers,...
Read MoreSide effects with vemurafenib/cobimetinib in advanced melanoma: is there an impact on survival?
In a nutshell This study investigated the impact of adverse events (AEs) of treatment with vemurafenib (Zelboraf) and cobimetinib (Cotellic) on survival in patients with melanoma. They found that early side effects requiring dose reduction had a positive effect on treatment outcomes. Some background Some melanoma tumors are caused by...
Read MoreSearching for patients with advanced melanoma to trial a new anti-cancer vaccine
In a nutshell This trial aims to find out if a new vaccine called NEO-PV-01 is safe to use in the treatment of advanced melanoma in combination with ipilimumab (Yervoy) or APX005M and with nivolumab (Opdivo). The main outcomes that will be measured will be side effects and response to treatment. The study is being conducted in the United...
Read MoreIs ultrasound surveillance of lymph nodes safe in patients with medium-risk melanoma?
In a nutshell This study wanted to find out if performing ultrasounds and performing clinical exams is a safe option to catch cancer that has spread to the lymph nodes in patients with melanoma. The study found that a significant number of tumors were found in lymph nodes by performing this type of surveillance. Some background The most common...
Read MoreTVEC therapy for patients with advanced stage melanoma
In a nutshell This study evaluated the safety and effectiveness of talimogene laherparepvec (TVEC) therapy for patients with melanoma that cannot be surgically removed (unresectable). The study found that TVEC therapy is an effective treatment for these patients, with minimal side effects. Some background Patients with localized melanoma that is...
Read MoreTVEC therapy for patients with advanced stage melanoma
In a nutshell This study evaluated the safety and effectiveness of talimogene laherparepvec (TVEC) therapy for patients with melanoma that cannot be surgically removed (unresectable). The study found that TVEC therapy is an effective treatment for these patients, with minimal side effects. Some background Patients with localized melanoma that is...
Read MoreSearching for patients with advanced melanoma to trial a new treatment combination
In a nutshell This trial aims to look at how safe and effective a new combination of lenvatinib (Lenvima) and pembrolizumab (Keytruda). The main outcome measured will be the number of patients who respond to treatment, and to what extent they respond. This study is being conducted in Spain, Sweden, and the United States. The details...
Read MoreSearching for patients with high-risk melanoma to test pembrolizumab before and after surgery
In a nutshell This trial aims to test the effectiveness of pembrolizumab (Keytruda) before and after surgery in patients with high-risk melanoma. The main outcome that will be measured will be survival without cancer-related events. The details Pembrolizumab is an anti-cancer medication that targets the immune system. It helps the immune system...
Read MoreSearching for patients with untreated advanced melanoma to trial a new personalized cancer vaccine
In a nutshell This trial aims to see if combining two medications, pembrolizumab (Keytruda) and RO7198457 (a new experimental vaccine) is better than just using pembrolizumab in treating advanced melanoma that has not been treated before. The main outcome that will be measured is how long the patients go without cancer growing. The study is being...
Read MoreSurvival in patients with melanoma treated with pembrolizumab
In a nutshell This study wanted to find out what the survival rates are of patients with melanoma treated with pembrolizumab (Keytruda). The study found that after 5 years, there was a good response to treatment overall. Some background Pembrolizumab is a new cancer treatment. It treats many different types of cancer. It works by using the immune...
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