In a nutshell This trial is examining the effectiveness and safety of 6MPH, a melanoma vaccine with adjuvants and a CDX-1127 monoclonal antibody in patients with melanoma. The main outcomes to be measured will be side effects and the response of the immune system. This trial is recruiting in Virginia, United States. The details A treatment option...
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Searching for patients with advanced melanoma to test this new treatment option
In a nutshell This phase 1/2 trial is examining the effectiveness and safety of KY1044 alone and in combination with atezolizumab (Tecentriq) for patients with advanced cancers who are not suitable for any other treatment or have failed all other treatment options. The main outcomes to be measured will be the occurrence and...
Read MoreEvaluating different doses of nivolumab plus ipilimumab for advanced melanoma
In a nutshell This study compared the safety of two different doses of nivolumab (Opdivo) plus ipilimumab (Yervoy) for patients with advanced melanoma. This study concluded that patients treated with nivolumab at 3mg/kg and ipilimumab at 1mg/kg had fewer side effects. Some background Advanced melanoma can be difficult to treat....
Read MoreLooking for patients with advanced melanoma to test new targeted therapy drug
In a nutshell This phase 2 trial will investigate the safety and efficacy of niraparib (Zejula) in advanced melanoma with abnormal genes. The main outcome will be the objective response rate (ORR). This trial is recruiting in California, United States. The details In many cases, melanoma is not diagnosed until an...
Read MoreIsolated limb infusion in patients with growing melanoma in one limb
In a nutshell This study evaluated the long-term outcomes of isolated limb infusion in patients with melanoma. This study found that this treatment was effective and safe. Some background Patients with melanoma can develop cancer that spreads or comes back after initial treatment as many small tumors. Removing these tumors by surgery is not...
Read MoreWhat are the benefits of combined dabrafenib and trametinib on patient-reported outcomes?
In a nutshell This study investigated the effect of dabrafenib (Tafinlar and trametinib (Mekinist) on patient-reported outcomes (PROs) in melanoma. They found that this treatment combination did not effect PROs. Some background Melanoma is a type of skin cancer. The prognosis for melanoma has improved in recent years. Targeted therapies...
Read MoreEvaluating immunotherapy with surgery for melanoma in the brain
In a nutshell This study investigated whether surgery before immunotherapy was more effective than immunotherapy alone for patients with melanoma that spread to the brain. This study concluded that patients who had surgery before immunotherapy survived for longer than patients who only had immunotherapy. Some background Melanoma is one of...
Read MoreLooking for patients with melanoma to test a new drug
In a nutshell This phase 2 trial will investigate the safety and effectiveness of a new targeted therapy drug, INCMGA00012 in advanced melanoma. The main outcome will be the overall response rate. This trial is recruiting in Texas, United States. The details Melanoma is a form of skin cancer. Some patients are diagnosed with advanced stage...
Read MoreLooking for patients with advanced melanoma to test a new treatment combination
In a nutshell This phase 2 trial will investigate the effectiveness and safety of ipilimumab (Yervoy) in combination with pembrolizumab (Keytruda) in patients with melanoma that has spread to the brain. The main outcome will be the clinical benefit rate and survival. The trial is recruiting in Texas, United States. The details...
Read MoreSearching for patients with BRAF positive melanoma to trial a new treatment regime
In a nutshell This trial aims to investigate the effects of the anti-cancer drugs dabrafenib (Taflinlar) and trametinib (Mekinist) on fever related side effects when treating patients with advanced melanoma that has been surgically removed. The main outcome that will be measured is the rate of fever and raised body temperature. The details High body...
Read MoreCan we predict treatment response using circulating tumor DNA in patients with melanoma?
In a nutshell This study investigated the use of circulating tumor DNA (ctDNA) to predict treatment response in advanced melanoma. They found that ctDNA levels can predict survival in these patients. Some background Melanoma is categorized, like many cancers, in stages. At stage 3 and above, survival rates can vary depending on...
Read MoreReviewing treatment options for patients with in-transit melanoma
In a nutshell This study reviewed treatment options for patients with in-transit melanoma. This study found that using treatments targeted to a specific area of the body may improve survival for these patients. Some background In-transit melanoma (ITM) is a type of cancer that is in the process of spreading throughout the body (metastasis). It can be...
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