In a nutshell This phase 3 trial will investigate the safety and effectiveness of pembrolizumab (Keytruda) and chemotherapy with or without canakinumab (Ilaris) in non-small cell lung cancer (NSCLC). The main outcomes will be side effects and survival rates. The details Non-small cell lung cancer (NSCLC) is the most common form of...
Read MoreIn a nutshell This study investigated the effect of immune-checkpoint inhibitors (ICIs) on influenza vaccination in patients with cancer. They found that influenza vaccination is safe in these patients. Some background Immune-checkpoint inhibitors (ICIs) are a new type of drug to treat cancer. ICIs can be effective in some advanced cancers, including...
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In a nutshell This trial is examining the effectiveness of a new cancer vaccine. The main outcomes to be measured are cancer response and side effects. This trial is recruiting in New York and Tennessee, US. The details The standard treatment for most cancers is surgery and chemotherapy. However, chemotherapy has a limited effectiveness and a high...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of tisotumab vedotin (TTV) for the treatment of solid tumors. The main outcome will be the response rate to treatment. This trial will take place in the United States, France, and Italy. The details Non-small cell lung cancer (NSCLC) is caused by excessive cell growth in...
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In a nutshell This paper provides an update on the current guidelines for the diagnosis and treatment of small-cell lung cancer. The paper summarized updates to immune therapy, systemic therapy, and radiotherapy. Some background Small cell lung cancer (SCLC) accounts for about 14% of all lung cancers. Nearly all of these cases are directly caused by...
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In a nutshell This study determined whether PET scanning helps improve overall survival for patients with small-cell lung cancer (SCLC). This study found that overall survival was significantly longer in patients with SCLC who had PET scanning. Some background Determining the disease stage for patients with SCLC is a key part of determining the...
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In a nutshell This study evaluated the safety of nivolumab (Opdivo) combined with radiation therapy for patients with advanced non-small cell lung cancer (NSCLC) that has spread. This study found that radiation therapy before or after treatment with nivolumab was not associated with an increased risk of severe side effects. Some background...
Read MoreIn a nutshell This trial aims to find out if combining nivolumab (Opdivo) and ipilimumab (Yervoy) with chemotherapy in patients with advanced non-small cell lung cancer is more effective than only treating with chemotherapy. The main outcome that will be measured is overall survival. The details There are a number of different treatment options...
Read MoreIn a nutshell This trial aims to find out how well nivolumab (Opdivo) and temozolomide (Temodal) work in treating small-cell lung cancer that has come back, is resistant to treatment or has spread through the body. The main outcome that will be measured is how well the patients respond to the treatment. The study is taking place in the United...
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In a nutshell This study determined whether stereotactic body radiation therapy (SBRT) was more effective than standard radiotherapy in patients with inoperable non-small cell lung cancer. The study found that SBRT led to better survival outcomes for these patients, with minimal side effects. Some background Tumor removal by surgery is the standard of...
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In a nutshell This study determined whether stereotactic body radiation therapy (SBRT) was more effective than standard radiotherapy in patients with inoperable non-small cell lung cancer. The study found that SBRT led to better survival outcomes for these patients, with minimal side effects. Some background Tumor removal by surgery is the standard of...
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In 1904, a physician wrote about a patient with leukemia who went into remission when he got the flu. Though the patient was not cured, it was a ray of hope at a time when there were no treatments for leukemia. Other cases were reported throughout the years of people with Burkitt’s Lymphoma and Hodgkin’s Lymphoma going into remission when they...
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