In a nutshell This study aimed to investigate the safety and effectiveness of venetoclax (Venclexta) and low-dose navitoclax (ABT-263) in combination with chemotherapy in patients with relapsed/refractory (r/r) acute lymphoblastic leukemia (ALL). This study concluded that this treatment option was well tolerated and...
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In a nutshell This study aimed to investigate whether venetoclax (Venclexta) is effective and well tolerated in patients with chronic lymphocytic leukemia (CLL) in a real-world setting. This study concluded that venetoclax is safe and effective in the real-world setting in these patients. Some background...
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In a nutshell This study aimed to investigate the long-term outcomes of sorafenib (Nexavar) treatment and maintenance therapy in patients with acute myeloid leukemia (AML). This study concluded that the addition of sorafenib to chemotherapy led to better outcomes for these patients. Some background...
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In a nutshell This study aimed to compare outcomes for allogeneic hematopoietic stem cell transplantation (alloHSCT) using haploidentical and matched sibling donors in patients with acute myeloid leukemia (AML). This study concluded that both donor types provided similar outcomes for these patients. Some background Allogeneic...
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In a nutshell This study compared different treatments for patients with chronic myelomonocytic leukemia (CMML). The data showed that hypomethylating agents (HMA) improved the outcomes compared with other treatments in these patients. Some background Chronic myelomonocytic leukemia (CMML) is a type of cancer that starts in blood-forming...
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In a nutshell This study aimed to investigate the impact of venetoclax (Venclexta) modification or early treatment ending on the outcomes of patients with relapsed/refractory chronic lymphocytic leukemia (CLL). This study concluded that venetoclax treatment modification did not impact outcomes but the early ending of...
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In a nutshell This study aimed to compare the outcomes of allogeneic (allo) and autologous (auto) hematopoietic stem cell transplant (HSCT) for patients with acute promyelocytic leukemia (APL) in second complete remission (CR2). This study concluded that autoHSCT resulted in better outcomes for these patients. Some background...
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In a nutshell This study aimed to investigate the long-term survival outcomes of treosulfan (Trecondi)-based versus busulfan (Myleran)-based conditioning treatment in patients with acute myeloid leukemia. This study concluded that treosulfan-based conditioning treatment may have better outcomes for these patients. Some background...
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In a nutshell This study aimed to investigate minimal residual disease (MRD) levels on the outcomes of children with very low-risk (VLR) acute lymphoblastic leukemia (ALL) treated with reduced intensity therapy. This study concluded that patients who had a low level of MRD had good outcomes with reduced intensity...
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In a nutshell This study aimed to investigate the long-term outcomes of nilotinib (Tasigna) versus imatinib (Gleevec) in patients with chronic-phase chronic myeloid leukemia (CP-CML). This study concluded that nilotinib provided good long-term outcomes for these patients. Some background CML results from a gene...
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In a nutshell This study aimed to investigate the effect of tyrosine kinase inhibitor (TKI) dose reduction in patients with chronic myeloid leukemia (CML) after achieving a major molecular response (MMR). This study concluded that the TKI dose reduction was safe and effective for the majority of these...
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In a nutshell This study aimed to investigate the GIMEMA LAL-1308 treatment protocol in young patients with Philadelphia chromosome-negative acute lymphoblastic leukemia. This study concluded that this treatment protocol was safe and effective for these patients. Some background Adolescents and young adults...
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