In a nutshell This report aimed to update recommendations from 2014 about primary prevention of invasive fungal infections in patients with hematological malignancies (blood cancers). There were several updates to the recommendations. Some background Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are hematological...
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In a nutshell This study compared the effectiveness of two types of tyrosine kinase inhibitors – imatinib (Gleevac) and bosutinib (Bosulif) – for chronic myeloid leukemia (CML). Researchers reported higher treatment response rates with bosutinib than with imatinib. Some background Many patients with CML...
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In a nutshell This study aimed to investigate if donor age and kinship affected the outcome of haploidentical hematopoietic cell transplantation for acute leukemia patients. This study concluded that both factors can affect the outcome for these patients. Some background Haploidentical hematopoietic cell transplantation (halpo-HCT)...
Read MoreIn a nutshell This study aimed to evaluate the effectiveness of levofloxacin (Levaquin) in preventing fever due to low white blood cells due to chemotherapy. This study concluded that oral levofloxacin reduced rates of febrile neutropenia. Some background Acute myeloid leukemia patients (AML) can experience complications...
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In a nutshell This study reviewed evidence on relapsing after discontinuing TKI therapy for chronic myeloid leukemia (CML). Some background Major molecular response (MMR) is a response to treatment where hardly any genetic abnormalities can be found in the bone marrow. Treatment-free remission (sustained MMR) is often considered the main goal of...
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In a nutshell This study examined infection risk in leukemia and lymphoma patients treated with CAR-T cell therapy, a new type of immunotherapy. Researchers reported that infection rates were comparable to other salvage therapies. Some background Chimeric antigen receptor (CAR) T-cell therapy helps the immune system to fight cancer cells. In...
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In a nutshell This study examined infection risk in leukemia and lymphoma patients treated with CAR-T cell therapy, a new type of immunotherapy. Researchers reported that infection rates were comparable to other salvage therapies. Some background Chimeric antigen receptor (CAR) T-cell therapy helps the immune system to fight cancer cells. In...
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In a nutshell This study examined the value of carrying out a bone marrow biopsy before beginning treatment for chronic lymphocytic leukemia (CLL). Researchers reported that a bone marrow biopsy at the time of diagnosis can help determine the need for treatment in CLL patients. Some background CLL is cancer of the blood and bone marrow. It is one...
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In a nutshell This study aimed to investigate the effectiveness of allogeneic hematopoietic stem cell transplant in patients with t(16;21) acute myeloid leukemia. This study concluded that allogenic hematopoietic stem cell transplant may be a suitable treatment for these patients. Some background Some patients with acute myeloid...
Read MoreIn a nutshell This study aimed to compare the effectiveness of myeloablative conditioning and reduced intensity conditioning before hematopoietic stem cell transplant in acute myeloid leukemia patients. This study concluded that myeloablative conditioning was more effective than reduced intensity conditioning. Some background A...
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In a nutshell This study aimed to investigate the usefulness of allogeneic stem cell transplantation in patients with BCR-ABL1 acute myeloid leukemia. This study concluded that allogenic stem cell transplantation is a good option for BCR-ABL1 acute myeloid leukemia patients who are in complete remission. Some background Some cases of acute...
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Video information: CLL patients can be prescribed steroids as a part of a treatment regimen, but how do they influence the body’s ability to reach remission? Expert, Dr. Michael Keating, joins us from The University of Texas MD Anderson Cancer Center, to describe the potential impact of steroids on treatment response. Transcript: Andrew...
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