In a nutshell This study looked at the link between low vitamin D levels and inflammation of the mouth (oral mucositis) in children with acute lymphoblastic leukemia treated with methotrexate (Rasuvo). Researchers found that vitamin D deficiency occurs commonly in these patients. Some background Vitamin D is an important mineral for the body to absorb...
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In a nutshell This study was a systematic review (looking at all available and relevant evidence) of the safety and effectiveness of different treatment options for elderly patients with acute myeloid leukemia (AML). The study found that azacitidine (Vidaza) was safe and more effective than intensive chemotherapy in these patients. Some...
Read MoreIn a nutshell This study aimed to investigate the safety and effectiveness of ibrutinib in older patients with chronic lymphocytic leukemia. This study concluded that ibrutinib is safe and effective in these patients. Some background Ibrutinib (Imbruvica) is a targeted therapy for chronic lymphocytic leukemia (CLL). Targeted therapies block...
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In a nutshell This study analyzed different types of induction chemotherapy regimes in secondary acute myeloid leukemia. The authors concluded that the FLAG combination had a high response rate and a low level of treatment-related side effects. Some background Secondary acute myeloid leukemia is a type of leukemia arising from a pre-existing...
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In a nutshell This study aimed to investigate if ponatinib is a suitable second-line treatment option for patients with chronic-phase chronic myeloid leukemia. This study concluded that ponatinib is a suitable option for these patients. Some background Ponatinib (Iclusig) is a tyrosine kinase inhibitor (TKI). TKIs work by blocking proteins...
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In a nutshell This study looked at the effect of using busulfan to delete blood cancer cells from the system before replacing them with normal cells in the treatment of leukaemia. The study found that busulfan therapy was effective in removing blood cancer cells before replacement, in the treatment of high-risk acute leukaemia. Some background Acute...
Read MoreIn a nutshell The study looked at the impact of other medical conditions (comorbidities) on the effectiveness of ibrutinib (Imbruvica) in the treatment of chronic lymphocytic leukemia (CLL). The study concluded that having a number of other conditions was associated with a poorer prognosis in CLL patients treated with ibrutinib. Some background...
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In a nutshell This study looked at the effect of treosulfan combined with fludarabine (Fludara) and low-dose radiotherapy in the treatment of children with acute myeloid leukemia (AML). The researchers found that treosulfan combined with these therapies improved successful graft transplantation in the treatment of AML. Some background Acute myeloid...
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In a nutshell This study looked at the effectiveness of mismatched donor stem cell transplantation (SCT) for treating children with high-risk relapse of acute lymphoblastic leukemia (ALL). Researchers found that mismatched donor SCT was useful but not as effective as matched donor SCT in children with high-risk ALL. Some background Acute lymphoblastic...
Read MoreIn a nutshell This study aimed to investigate the effectiveness and safety of a lower dose of dasatinib in chronic phase chronic myeloid leukemia patients. This study concluded that the lower dose of dasatinib was as effective and safer than the standard dose in these patients. Some background Dasatinib (Sprycel) is a tyrosine kinase inhibitor...
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In a nutshell This study aimed to investigate the effectiveness of an obinutuzumab and bendamustine combination in chronic lymphocytic leukemia patients. This study concluded that this combination appears to be effective in these patients and has manageable side effects. Some background Obinutuzumab (Gazyva) is a monoclonal antibody. Monoclonal...
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In a nutshell This study aimed to investigate the effectiveness and safety of bosutinib as a second line therapy for patients with chronic phase chronic myeloid leukemia (CML). This study concluded that bosutinib was effective and safe for these patients as a second line therapy. Some background Bosutinib (bosulif) is a tyrosine kinase inhibitor (TKI...
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