In a nutshell This study investigated the interactions between tyrosine kinase inhibitors and other drugs taken at the same time in patients with chronic myeloid leukemia. This study concluded that drug interactions were found in a significant number of patients, with mild side effects. Some background Imatinib (Gleevec) and similar drugs are the...
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In a nutshell This study compared two different transplant therapies used to treat acute myeloid leukaemia (AML), unmanipulated haploidentical stem cell treatment (Haplo-SCT) and HLA-matched unrelated donor stem cell transplantation (MUD). The study found that both options are useful in treating AML but MUD may have increased risk of graft versus host...
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In a nutshell This study compared two different transplant therapies used to treat acute myeloid leukaemia (AML), unmanipulated haploidentical stem cell treatment (Haplo-SCT) and HLA-matched unrelated donor stem cell transplantation (MUD). The study found that both options are useful in treating AML but MUD may have increased risk of graft versus host...
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In a nutshell This study looked at the safety and effectiveness of adding plerixafor (Mozibil) to FLAG-Ida (fludarabine [Fludara], idarubicin [Idamycin], cytarabine [Cytosar-U] and G-CSF) in the treatment of patients with relapsed acute myeloid leukemia. The study found that adding plerixafor to FLAG-Ida treatment (together called PLERIFLAG) was a safe...
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In a nutshell This study looked at the effect of neutrophil recovery time (NRT – the return of white blood cells after treatment, that fight infection) on infections and relapse (return of disease) in children with acute myeloid leukaemia (AML). The study found that longer NRT was linked with increased risk of severe infections and relapse after...
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In a nutshell This study looked at the effect of neutrophil recovery time (NRT – the return of white blood cells after treatment, that fight infection) on infections and relapse (return of disease) in children with acute myeloid leukaemia (AML). The study found that longer NRT was linked with increased risk of severe infections and relapse after...
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In a nutshell This study compared two stem cell therapies called unmanipulated haploidentical and matched sibling donor transplant in the treatment of acute myeloid leukemia (AML). The study concluded that matched sibling donor transplant was more effective in the treatment of AML. Some background AML is a cancer of the white blood cells in...
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In a nutshell This study compared the long-term effects of total body irradiation (TBI – powerful radiotherapy) plus cyclophosphamide (Cytoxan) with busulfan (Myleran) plus cyclophosphamide as part of the treatment for acute lymphoblastic leukemia (ALL). Researchers found that TBI is effective in younger patients and had higher overall survival...
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In a nutshell This study aimed to investigate if allogeneic hematopoietic cell transplantation is effective in patients who have progressed from chronic lymphocytic leukemia to Richter syndrome. This study concluded that allogeneic hematopoietic cell transplant is effective for these patients if they had an objective response before...
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In a nutshell This study examined the effect of graft versus host disease on relapse rates in children with acute leukemia. This study concluded that graft versus host disease may protect against relapse, but they did not see an effect on survival. Some background One complication following an allogeneic stem cell transplant (transplant using donor...
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In a nutshell This study compared the safety and effectiveness of using the same treatment protocol in patients with Acute Lymphoblastic Leukemia (ALL) and Down’s Syndrome (DS) compared to patients with ALL without Down’s Syndrome. The study found that treatment for ALL was effective in both DS and non-DS patients but with more side effects...
Read MoreIn a nutshell This study aimed to investigate the safety of venetoclax (Venclexta) in patients with relapsed/refractory chronic lymphocytic leukemia. This study concluded that venetoclax is safe in these patients as a long-term continuous therapy. Some background Venetoclax is a treatment used for patients with relapsed/refractory (RR)...
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