In a nutshell This study wanted to compare the effectiveness of chlorambucil (Leukeran) plus either obinutuzumab (Gazyva) or rituximab (Rituxan) in the treatment of frail patients with chronic lymphocytic leukemia (CLL). Researchers found that chlorambucil with obinutuzumab (G-Clb) was more effective than with rituximab (R-Clb) in these...
Read MoreIn a nutshell This study compared the safety and effectiveness of donor peripheral blood (PB) with bone marrow (BM) transplant in the treatment of leukemia. Researchers found that bone marrow transplants are safer and more effective in the treatment of leukemia. Some background Leukemia is a cancer of the bone marrow. It may lead to abnormal immune...
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In a nutshell This study aimed to assess the usage and safety of biological treatment to treat chronic myeloid leukemia (CML). Researchers found that nilotinib (Tasigna) has a better profile as a first-line drug in the treatment of CML. Some background Chronic myeloid leukemia is a cancer of the bone marrow. This leads to abnormal immune...
Read MoreIn a nutshell This trial is comparing the effectiveness of ponatinib (Iclusig) with imatinib (Gleevec) together with low-dose standard chemotherapy for the treatment of patients with acute lymphoblastic leukemia (ALL). The main outcome to be measured is minimal residual disease (low levels of cancer markers in the blood). This study will...
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In a nutshell This study looked at the safety and effectiveness of ibrutinib (Imbruvica) added to bendamustine (Treanda) and rituximab (Rituxan) in the treatment of unresponsive chronic lymphocytic leukemia. Researchers found that this treatment improved survival in these patients. Some background Chronic lymphocytic leukemia (CLL) is a...
Read MoreIn a nutshell This study wanted to look at the effect of ibrutinib (Imbruvica) on white cell count (immune cells) in patients with chronic lymphocytic leukemia. Researchers found that increases in white cell count during ibrutinib treatment were normal and did not indicate poor outcomes in these patients. Some background Chronic lymphocytic leukemia...
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In a nutshell The study looked at the safety and effectiveness of ponatinib (Iclusig) in the treatment of chronic myeloid leukemia (CML). Researchers found that ponatinib was safe and effective in previously treated patients with CML. Some background Chronic myeloid leukemia is a type of cancer of the bone marrow. This can lead to abnormal immune...
Read MoreIn a nutshell This study aimed to investigate if enalapril influences anthracycline-induced cardiotoxicity in children with leukemia and lymphoma. This study concluded that enalapril has a role in reducing anthracycline-induced cardiotoxicity in these patients. Some background Anthracyclines are a class of chemotherapy drugs that can be used for...
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In a nutshell This study looked at the safety and effectiveness of bosutinib (Bosulif) in the treatment of chronic myeloid leukemia (CML). Researchers found that bosutinib was effective in patients who have failed other similar drug treatments. Some background Chronic myeloid leukemia (CML) is a cancer of the bone marrow. This can lead to abnormal...
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In a nutshell This study reviewed the evidence for stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL). Researchers found that SCT is an effective treatment option in patients with high risk of ALL coming back. Matched donors or siblings are the preferred stem cell donors. Some background ALL is a cancer of the bone...
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In a nutshell This study examined the effectiveness of vibration therapy on patients receiving chemotherapy for leukemia and lymphoma. Researchers found that vibration therapy improved daily function in these patients. Some background Exercise is proven to be effective in improving outcomes of patients with cancer. Chemotherapy treatment can make...
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In a nutshell This study aimed to investigate the outcomes of patients with chronic myeloid leukemia who were treated with tyrosine kinase inhibitors. This study concluded that this treatment increased survival for new and older CML cases. Some background Imatinib (Gleevec) was the first tyrosine kinase inhibitor (TKI) used to treat chronic myeloid...
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