In a nutshell This study looked at using platelet count to measure response to decitabine (Dacogen) chemotherapy in elderly patients with acute myeloid leukemia (AML). Researchers found that recovered platelet count after treatment is linked with a better response to treatment. Some background Elderly patients often have a poorer response to leukemia...
Read MoreIn a nutshell This trial is examining the effectiveness of a new drug called uproleselan for patients with acute myeloid leukemia (AML). The main outcome to be measured will be overall survival. This study is being conducted in the United States. The details Acute myeloid leukemia (AML) is a cancer of the bone marrow. It leads to an abnormal immune...
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In a nutshell This study aimed to assess the long-term safety and effectiveness of adding ponatinib (Iclusig) to intensive chemotherapy in the treatment of acute lymphoblastic leukemia. The study found that this treatment is effective on the long-term for these patients. Some background Acute lymphoblastic leukemia (ALL) is a cancer of the bone...
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In a nutshell This study aimed to investigate if imatinib (Gleevec) levels can predict responses for patients with newly diagnosed chronic myeloid leukemia. This study concluded that imatinib trough levels influenced treatment responses in these patients. Some background Imatinib is a targeted treatment used to treat chronic...
Read MoreIn a nutshell The study looked at the safety and effectiveness of adding dexamethasone (Decadron) to lenalidomide (Revlimid) in previously untreated patients with chronic lymphocytic leukemia (CLL). Researchers concluded that lenalidomide plus dexamethasone is an effective treatment for CLL. Some background Chronic lymphocytic leukemia (CLL) is a...
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In a nutshell This study wanted to assess the outcomes of chemoimmunotherapy in older patients with chronic lymphocytic leukemia (CLL). Researchers found that chemoimmunotherapy is safe and effective in these patients. Some background Chronic lymphocytic leukemia is a cancer of the bone marrow. It is often associated with older patients and...
Read MoreIn a nutshell This study compared the effectiveness of regular myeloablative conditioning (MAC; chemotherapy that kills cells in the bone marrow, including cancer cells before a transplant) with reduced-intensity conditioning (RIC) in the treatment of chronic myeloid leukemia. Researchers found that RIC had similar effectiveness and less risk of...
Read MoreIn a nutshell This study wanted to assess the safety and effectiveness of inotuzumab ozogamicin (InO; Besponsa) for the treatment of children with unresponsive acute lymphoblastic leukemia (ALL). Researchers found that InO was safe and effective in this group of patients. Some background Acute lymphoblastic leukemia (ALL) is a cancer of the bone...
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In a nutshell This study reviewed the changes in survival and outcome in patients treated with tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML). Researchers found that the introduction of TKI treatment has improved outcomes and survival. Some background Chronic myeloid leukemia is a disease of the bone marrow. It is often...
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In a nutshell This study is an update on the management of acute myeloid leukemia (AML). Researchers found that certain abnormal genes affect response to different medications used to treat AML. Some background Acute myeloid leukemia is a cancer of the bone marrow. It may be linked with abnormal genes that can affect response to treatment. Some genes...
Read MoreIn a nutshell This trial is comparing the effect of crenolanib with midostaurin (Rydapt) in the treatment of acute myeloid leukemia. The main outcome to be measured is event-free survival (EFS – survival time after treatment with cancer not coming back or getting worse). The details Acute myeloid leukemia (AML) is a cancer of the bone...
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In a nutshell This study aimed to identify risk factors of tiredness in children treated for leukemia and lymphoma or who received a stem cell transplant. Researchers found that older age and active treatment were risk factors for developing severe tiredness in these patients. Some background Cancer treatment leads to severe tiredness (fatigue) over...
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