In a nutshell This study looked at the effectiveness of stopping ibrutinib (Imbruvica) or using it at different stages of treatment in patients with chronic lymphocytic leukemia (CLL). Researchers found that ibrutinib was effective in patients with CLL at all stages of treatment. Some background CLL is a cancer of the immune system. I may be...
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In a nutshell This study looked at the effectiveness of venetoclax (Venclexta) in the treatment of relapsed or unresponsive chronic lymphocytic leukemia (CLL). Researchers found venetoclax improved outcomes in these patients. Some background CLL is a cancer of the bone marrow. This may lead to an abnormal immune system. It is also often...
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In a nutshell This study examined if ibrutinib alone, or combined with rituximab is a more effective treatment for chronic lymphocytic leukemia (CLL). This study concluded that both treatments have similar survival, but adding rituximab to ibrutinib leads to faster remissions. Some background CLL is a cancer of the bone marrow. This leads to...
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In a nutshell This study aimed to investigate the safety and effectiveness of ibrutinib (Imbruvica) combined with umbralisib for patients with released/unresponsive chronic lymphocytic leukemia (CLL). This study concluded that the combination of umbralisib and ibrutinib is well tolerated and effective in relapsed/unresponsive CLL. Some background...
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In a nutshell This study looked at the use of medication delivered to the spinal area (intrathecal) in patients with acute lymphoblastic leukemia (ALL). Researchers showed that this may be used instead of radiation to the head in these patients, with similar outcomes. Some background Acute lymphoblastic leukemia is a cancer of the immune system that...
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In a nutshell This study examined if pediatric treatment is effective in older adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL). This study concluded that pediatric treatment is effective in AYA under 40 with ALL. Some background ALL is a cancer of the bone marrow. It leads to abnormal immune cells in the blood. Some studies...
Read MoreIn a nutshell This study reviewed research on the effectiveness of single and combined therapies for chronic lymphocytic leukemia (CLL). Researchers found that combining drugs may be more effective in the treatment of CLL. Some background Chronic lymphocytic leukemia is a blood cancer of the bone marrow and immune system. It is...
Read MoreIn a nutshell This study looked at the management of side effects of bosutinib (Bosulif) in the treatment of chronic myeloid leukemia. Researchers found that bosutinib was safe in the treatment of patients in whom other medications have failed. Some background Chronic myeloid leukemia is a cancer of the bone marrow. It can lead to an abnormal...
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In a nutshell This study was a review of the most recent guidelines of diagnosis and treatment of chronic lymphocytic leukemia (CLL) that has transformed into aggressive lymphoma. Some background Chronic lymphocytic leukemia is a cancer of the bone marrow and immune system. Over time, it may develop into a cancer of the immune tissues called a...
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In a nutshell This study aimed to investigate the effects of reducing the dose of ibrutinib on the outcomes of patients with chronic lymphocytic leukemia. This study concluded that dose reduction has no significant effect on the outcomes of these patients. Some background Ibrutinib (Imbruvica) is a targeted therapy used to treat chronic...
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In a nutshell This study evaluated the safety and effectiveness of ibrutinib (Imbruvica) plus nivolumab (Opdivo) for relapsed or unresponsive chronic lymphocytic leukemia (CLL). This study concluded that this treatment was well-tolerated and showed promising effectiveness in these patients. Some background Treatment remains challenging for...
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In a nutshell This study assessed if monitoring the minimal residual disease (MRD) levels in chronic lymphocytic leukemia (CLL) can help guide future treatment strategies. This study concluded MRD monitoring can be used to predict outcomes and may help guide future treatment choices. Some background Chronic lymphocytic leukemia is a cancer of...
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