In a nutshell This study was an update on the guidelines of stopping tyrosine kinase inhibitor (TKI) therapy in the treatment of chronic myeloid leukemia (CML). New guidelines confirm the safety of stopping TKI therapy in patients with CML. Some background Chronic myeloid leukemia is often treated with TKI therapy. These are drugs which...
Read MoreIn a nutshell This study wanted to find out if a low platelet count at diagnosis of acute myeloid leukemia (AML) was linked to rates of survival. Researchers found that low platelet count at diagnosis was linked to higher survival in these patients. Some background Acute myeloid leukemia (AML) is a cancer of the bone marrow. It may lead to an...
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In a nutshell This study looked at the effect of stopping ponatinib (Iclusig) therapy in patients with chronic myeloid leukemia (CML). Researchers found that overall survival was high in these patients who stopped ponatinib. Some background Ponatinib is a drug that is used to treat chronic myeloid leukemia (CML). It has many side effects related...
Read MoreIn a nutshell This study summarised the side effects of ibrutinib (Imbruvica) and how to manage them. Some background Ibrutinib is an FDA approved drug used to treat lymphoma and leukemia. It works on the immune cells in the body which may lead to many side effects. These include diarrhea, upper respiratory infections, bleeding, tiredness,...
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In a nutshell This study examined the impact of aspergillosis lung infection on the outcomes of patients with acute leukemia. Researchers found that this infection can reduce survival in these patients. Some background Acute leukemia is a cancer of the bone marrow. This leads to an abnormal immune system. Aspergillosis is a fungal infection that...
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In a nutshell This study looked at the causes and treatment of anemia in patients with acute lymphoblastic leukemia (ALL). Researchers found that early diagnosis and treatment of anemia had better outcomes for these patients. Some background Anemia is a low ability of the blood to carry oxygen. This leads to tiredness and low energy....
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In a nutshell This study investigated the occurrence of graft-versus-host disease (GVHD) in pediatric patients who underwent an allogeneic stem cell transplant (alloSCT). This study concluded that both umbilical cord blood cells and bone marrow cells led to similar rates of GVHD in children with acute leukemia. Some background Allogeneic stem cell...
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In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...
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In a nutshell This study is evaluating how well CPI-613 plus chemotherapy works in older patients with acute myeloid leukemia (AML) that has come back or stopped responding to treatment. The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This trial is taking place across the United...
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In a nutshell This study aimed to investigate the outcomes of allogeneic stem cell transplant (allo-SCT) after treatment with inotuzumab ozogamicin (Besponsa) for patients with relapsed/unresponsive acute lymphoblastic leukemia (ALL). This study concluded that allo-SCT provided optimal long-term survival benefit for these patients. Some...
Read MoreIn a nutshell This study aimed to investigate infection rates in children with acute lymphoblastic leukemia who received stem cell transplant from unrelated donors. This study concluded that these patients experience higher infection rates than other patients. Some background Allogeneic hematopoietic stem cell transplantation...
Read MoreIn a nutshell This study aimed to compare frontline therapies in older patients with acute myeloid leukemia. This study concluded that hypomethylating agents provided better overall survival for these patients. Some background Older patients with acute myeloid leukemia (AML), more frequently...
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