In a nutshell This study looked at the effectiveness of interferon-alpha (IntronA) treatment in patients with chronic myeloid leukemia (CML) with residual disease after transplantation. Researchers found that this treatment may be useful in patients with signs of disease after transplant. Some background Chronic myeloid leukemia is a cancer...
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In a nutshell This study aimed to investigate the effectiveness and safety of dasatinib as a second- and third-line therapy in patients with chronic phase chronic myeloid leukemia (CP-CML). This study concluded that dasatinib was effective as a second-line treatment in these patients but showed limited effectiveness as a third-line treatment....
Read MoreIn a nutshell This phase 2 study is evaluating the effectiveness of a new combination therapy for chronic lymphocytic leukemia (CLL). The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This study is recruiting in Rochester, New York, US. The details Typical treatments for CLL...
Read MoreIn a nutshell This study will investigate the effects of high-pressure oxygen on the transplant of umbilical cord blood stem cells in patients with blood cancers. The main outcome that will be measured is the time it takes for white blood cells to recover after treatment. This trial is recruiting in New York, US. The details Stem cell transplant (SCT)...
Read MoreIn a nutshell This study is searching for patients with chronic myeloid leukemia (CML) to try a new drug ruxolitinib (NSC-752295) with BCR-ABL Tyrosine Kinase Inhibitors. The main outcome that will be measured is the rate of significant reduction of the BCR-ABL marker. This trial is recruiting across the United States. The details BCR-ABL is a protein...
Read MoreIn a nutshell This study aimed to investigate the effectiveness of the venetoclax (Venclexta) – obinutuzumab (Gazyva) combination in patients with chronic lymphocytic leukemia (CLL) and a coexisting condition. This study concluded that this combination provided better outcomes for these patients than a chlorambucil...
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In a nutshell This study looked at the use of blood markers to measure treatment activity of L-asparaginase in acute lymphoblastic leukemia (ALL). Researchers found that antithrombin (AT) and fibrinogen (FIB) could be used to measure effective levels of L-asparaginase in these patients. Some background L-asparaginase is a treatment for acute...
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In a nutshell This study looked at the safety and effectiveness of acalabrutinib (Calquence) in the treatment of patients with chronic lymphocytic leukemia (CLL). Researchers found that acalabrutinib had a high response rate and low side effects in these patients. Some background Chronic lymphocytic leukemia is a cancer of the bone...
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In a nutshell This study looked at the risk of kidney damage in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitor (TKI) therapy. Researchers found that imatinib (Gleevec) was linked with greater damage to the kidney compared to nilotinib (Tasigna) or dasatinib (Sprycel) in these patients. Some background...
Read MoreIn a nutshell This trial is searching for patients to try a combination of glasdegib (Daurismo) with azacitidine (Vidaza) for acute myeloid leukemia (AML) that has not been treated. The main outcome that will be measured is overall survival. The details Different anti-cancer drugs can be used in different combinations and may have different effects....
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In a nutshell This study compared the safety and effectiveness of blinatumomab (Blincyto) with chemotherapy in the treatment of acute lymphoblastic leukemia (ALL). Researchers found the survival was higher with blinatumomab than chemotherapy alone. Some background Patients with unresponsive or relapsed ALL treated with chemotherapy have...
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In a nutshell This study wanted to research if the combination therapy of ibrutinib (Imbruvica) and venetoclax (Venclexta) was effective in the treatment of chronic lymphocytic leukemia (CLL). Researchers found that this combination therapy was an effective treatment for high-risk and older patients with CLL. Some background Chronic...
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