In a nutshell This study aimed to investigate treatment-free remission after dasatinib treatment in patients with chronic-phase chronic myeloid leukemia. This study concluded that it is possible to stop dasatinib treatment in these patients once they have achieved a deep molecular response. Some...
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In a nutshell This review aimed to look at ponatinib treatment for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia with a focus on cardiovascular management. This review concluded that ponatinib can lead to increased cardiovascular...
Read MoreIn a nutshell This study aimed to investigate the association of uric acid levels before a stem cell transplant and patient outcomes. This study concluded that high uric acid levels before the transplant led to increased mortality. Some background Uric acid is a product of metabolic breakdown and is a normal component of urine. It can also be a...
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In a nutshell This study aimed to investigate the occurrence of late chronic anemia in older patients with chronic myeloid leukemia treated with imatinib. This study concluded that late chronic anemia is common in these patients. Some background Imatinib (Gleevec) is a tyrosine kinase inhibitor (TKI). This is...
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In a nutshell This study aimed to evaluate the risk for second primary cancers in chronic lymphocytic leukemia survivors compared to the general population. This study concluded that active survivorship plans and long-term surveillance for second primary cancers is crucial for improved outcomes in survivors of chronic...
Read MoreIn a nutshell This study aimed to investigate the long-term survival outcomes for patients with acute myeloid leukemia receiving conditioning regimen involving fractionated total body irradiation combined with cyclophosphamide or etoposide before transplant. This study concluded that this...
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In a nutshell The study aimed to identify cardiovascular (heart and blood vessel) adverse drug reactions (CV-ADR) associated with ibrutinib treatment. This study concluded that severe and sometimes fatal cardiac events occur in patients exposed to ibrutinib. Some background Ibrutinib (Imbruvica) is a...
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In a nutshell This study aimed to investigate the safety and effectiveness of stopping nilotinib treatment in patients with chronic-phase chronic myelogenous leukemia. This study concluded that stopping nilotinib after two years of consolidation treatment was safe and effective. Some background...
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In a nutshell This study aimed to compare the side effects associated of ibrutinib treatment for elderly patients with chronic lymphoid leukemia. This study concluded that ibrutinib treatment in these patients was not associated with significantly higher risks of anemia (low red blood cells), thrombocytopenia...
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In a nutshell This article aimed to review the advances in the treatment of acute lymphoblastic leukemia in adults. This article concluded that the development of improved treatments has led to better outcomes for these patients. Some background Acute lymphoblastic leukemia (ALL) is an aggressive...
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In a nutshell This study aimed to investigate the outcomes of allogeneic transplantation in patients with core-binding factor acute myeloid leukemia in second complete remission. This study concluded that transplant was effective in a large proportion of these patients. Some background Core binding factor acute myeloid...
Read MoreIn a nutshell This trial is examining the effectiveness of modified stem cell transplants (SCT) donated by patient relatives, which have certain immune cells removed to prevent transplant rejection in patients with leukemia and lymphoma. The main outcome will be the maximum dose of SCT that can be given safely and is effective. This study is recruiting...
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