In a nutshell This study aimed to investigate if asciminib was effective in patients with chronic myeloid leukemia who had resistance or unacceptable side effects to other tyrosine kinase inhibitors. This study concluded that asciminib showed promise in these patients. Some background Asciminib is a...
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In a nutshell This study aimed to investigate the safety and effectiveness of decitabine in older patients with acute myeloid leukemia. This study concluded that decitabine is safe and effective in these patients. Some background The occurrence of acute myeloid leukemia (AML) increases with age. The overall prognosis...
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In a nutshell This study investigated if a higher dose of PEG-asparaginase (Oncaspar) with early induction and additional triple intrathecal therapy (TIT) can prevent relapse in the brain in children with acute lymphoblastic leukemia (ALL). The authors found that additional TIT during early induction improved the outcomes of these...
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In a nutshell This study aimed to investigate the occurrence of hematological (blood-related) side effects in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. This study concluded that bone marrow fibrosis at diagnosis was a predictor of hematological side effects from tyrosine...
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In a nutshell This study aimed to investigate ponatinib combined with conventional therapy in recurrent Philadelphia chromosome-positive central nervous system leukemia with a BCR-ABL T315I mutation after allogeneic hematopoietic stem cell transplant. This study concluded that ponatinib may be effective for these...
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In a nutshell This study aimed to investigate the use of ofatumumab maintenance treatment in patients with relapsed chronic lymphocytic leukemia. This study concluded that this treatment significantly prolonged progression-free survival in these patients and was well tolerated. Some background Ofatumumab (Arzerra) is a...
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In a nutshell This study aimed to investigate if minimal residual disease negativity is useful as a prognostic factor after inotuzumab ozogamicin treatment in patients with relapsed/refractory acute lymphoblastic leukemia. This study concluded minimal residual negativity with complete remission is associated with a better...
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In a nutshell This study aimed to investigate the safety and effectiveness of imatinib treatment in patients with newly diagnosed chronic myeloid leukemia. This study concluded that patients of lower weight and older age are more vulnerable to side effects. Some background Imatinib (Gleevec) is a targeted therapy...
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In a nutshell This study evaluated if the intensified postinduction therapy is safe and effective to treat children with standard-risk (SR) B-cell acute lymphoblastic leukemia (B-ALL). The study concluded that the treatment excellently impacted survival among patients, but further intensifying the therapy might be unnecessary. Some background B-ALL is...
Read MoreIn a nutshell This study aimed to investigate the effects of valproate (Depakene) and all-trans retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia. This study concluded that the addition of ATRA to decitabine (Dacogen) chemotherapy led to a higher remission rate and survival...
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In a nutshell This trial is evaluating the effectiveness of KRT-232 for the treatment of acute myeloid leukemia (AML). The main outcomes are the number of patients who achieve complete remission, and how many patients stop treatment due to side effects. This study is being conducted in Columbus, Ohio, United States. The details AML is a...
Read MoreIn a nutshell This study reviewed treatment options for advanced phase chronic myeloid leukemia. This study concluded that managing advanced phase chronic myeloid leukemia remains challenging and treatment options include tyrosine kinase inhibitors, chemotherapy, and transplant. Some background Chronic myeloid leukemia (CML) can be...
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