In a nutshell The study investigated whether blinatumomab (Blincyto) can be used for salvage therapy before hematopoietic cell transplantation (HCT) in patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). The main finding was that blinatumomab can be safely and effectively used in patients with r/r B-ALL before HCT. Some...
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Ibrutinib versus other standard treatments for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate the effectiveness of ibrutinib compared to other standard treatments in patients with chronic lymphocytic leukemia. This study concluded that ibrutinib is more effective than other standard treatments in these patients. Some background Standard treatments for...
Read MoreAdding cladribine to standard induction chemotherapy for patients with acute myeloid leukemia
In a nutshell This study aimed to investigate the addition of cladribine to standard induction chemotherapy in patients with acute myeloid leukemia. This study concluded that the patients treated with added cladribine had better outcomes when compared to patients who received standard induction chemotherapy...
Read MoreEvaluating the effects of venetoclax and obinutuzumab in patients with untreated chronic lymphocytic leukemia
In a nutshell The study evaluated the treatment benefits of venetoclax (Venclexta) and obinutuzumab (Gazyva) in patients with untreated chronic lymphocytic leukemia (CLL) and coexisting medical conditions. The main finding was that the combination therapy improved outcomes in these patients. Some background Most patients with CLL are older...
Read MoreEvaluating alisertib combined with chemotherapy in acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of alisertib combined with induction chemotherapy in patients with high-risk acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some background Alisertib is a type of targeted...
Read MoreThe risks of invasive fungal infections in patients treated with venetoclax and hypomethylating agents for acute myeloid leukemia
In a nutshell The study examined the risks of invasive fungal infections (IFIs) in patients with acute myeloid leukemia (AML), who were treated with venetoclax (Venclexta) and hypomethylating agents (VEN-HMAs). The authors found that the occurrence of IFIs was low during VEN-HMA treatment. Some background Venetoclax is a targeted therapy. It blocks...
Read MoreEffects of TKIs on glucose and lipid metabolism in patients with chronic phase chronic myeloid leukemia
In a nutshell This study aimed to evaluate glucose (blood sugar) and lipid (fat) metabolism between dasatinib, nilotinib, and imatinib in patients with chronic-phase chronic myeloid leukemia. This study concluded that dasatinib and nilotinib had a negative impact on glucose and lipid...
Read MorePremedication with methylprednisolone before obinutuzumab treatment in patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate if pretreatment with methylprednisolone would reduce infusion-related reactions associated with obinutuzumab use in patients with chronic lymphocytic leukemia. This study concluded that premedication with methylprednisolone reduces infusion-related reactions...
Read MoreComparing time to next treatment, health care resource utilization and costs between patients with chronic lymphocytic treated with ibrutinib or chemoimmunotherapy
In a nutshell This study aimed to compare health care costs, resource utilization and time to the next treatment in patients with chronic lymphocytic leukemia who received ibrutinib or chemoimmunotherapy. This study concluded that ibrutinib in these patients was associated with lower medical costs and longer time...
Read MoreFactors associated with patient-reported symptoms in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
In a nutshell This study aimed to investigate which factors are associated with patient-reported symptoms and their impact on quality-of-life in patients with chronic myeloid leukemia who are receiving tyrosine kinase inhibitors. This study concluded that there were a number of factors associated with patient-reported symptoms in these...
Read MoreGemtuzumab ozogamicin treatment in acute myeloid leukemia
In a nutshell This study aimed to investigate if gemtuzumab ozogamicin with induction and consolidation treatment was suitable for patients with acute myeloid leukemia and abnormal genes. This study concluded that patients who achieve complete remission after induction therapy and treated with gemtuzumab ozogamicin had...
Read MoreIs asparaginase-associated pancreatitis dependent on the age of patients with acute lymphoblastic leukemia?
In a nutshell This study evaluated whether the risk and severity of asparaginase-associated pancreatitis (AAP) depend on the age of patients with acute lymphoblastic leukemia (ALL). The main finding was that the AAP risk was higher in adolescents and adults compared to younger children. Some background Asparaginase (ASP; Oncaspar) is an important...
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