In a nutshell This review summarized recent changes in treatments of patients with chronic myeloid leukemia (CML). Some background Patients with CML carry a cancerous tyrosine kinase (TK) enzyme called BCR-ABL1. Traditionally CML had been treated by non-specific drugs with side effects. Stem cell transplants are alternatives but not...
Read MoreLeukemia Posts on Medivizor
Comparing outcomes in acute myeloid leukemia patients treated with FLAG with/without idarubicin vs traditional 3+7 treatment
In a nutshell This study aimed to compare post-remission survival for patients with acute myeloid leukemia treated with 2 different regimens. This study concluded that FLAG with or without idarubicin treatment has better post-remission survival when compared to standard 3+7 treatment for these patients. Some background...
Read MoreClofarabine, cytarabine and mitoxantrone for the treatment of relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to investigate the effectiveness and safety of clofarabine, cytarabine, and mitoxantrone (CLAM) in relapsed or refractory (unresponsive) acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some...
Read MoreManaging joint and muscle pain in patients with chronic lymphocytic leukemia treated with ibrutinib
In a nutshell The study evaluated the occurrence and risks of joint/muscle pain as side effects of ibrutinib (Imbruvica) in patients with chronic lymphocytic leukemia (CLL). The authors found that 36% of patients developed joint/muscle pain and most were younger and females receiving ibrutinib as the first treatment. Some background Ibrutinib kills...
Read MoreThe effects of hydroxychloroquine and imatinib on treatment outcomes in patients with chronic myeloid leukemia
In a nutshell The study evaluated the combined effects of imatinib (IM; Gleevec) and hydroxychloroquine (HCQ; Plaquenil) in patients with chronic-phase chronic myeloid leukemia (CP-CML) and residual leukemic stem cells. The authors found that this combination safely and moderately improved treatment outcomes in such patients compared to IM alone. Some...
Read MoreLong-term nilotinib treatment for newly diagnosed chronic-phase chronic myeloid leukemia
In a nutshell This study aimed to investigate if nilotinib was safe and effective as a long-term treatment in patients with chronic-phase chronic myeloid leukemia. This study concluded that nilotinib is safe and effective in the long-term in these patients. Some background Nilotinib...
Read MoreIbrutinib for first-line and relapsed/refractory chronic lymphocytic leukemia: long-term outcomes
In a nutshell This study aimed to investigate the long-term safety and effectiveness of ibrutinib in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. This study concluded that ibrutinib was safe and effective in the long-term in this group. Some background Ibrutinib (Imbruvica) is a...
Read MoreLong-term outcomes for acute myeloid leukemia patients treated with reduced intensity conditioning and hematopoietic stem cell transplant
In a nutshell This study aimed to investigate the long-term outcomes for patients with acute myeloid leukemia who received reduced-intensity conditioning and allogeneic stem cell transplant. This study concluded that this treatment is safe and effective in these patients in the long-term. Some background One of the standard...
Read MoreTreating adolescent and young adult patients with acute lymphoblastic leukemia
In a nutshell The review summarized results from recent studies that tested pediatric treatments for acute lymphoblastic leukemia (ALL) on adolescents and young adults (AYA). The main conclusion was that the pediatric treatment for AYA patients with ALL will result in better outcomes and survival. Some background Latest ALL treatments have...
Read MoreLiposomal vincristine for patients with newly diagnosed acute lymphoblastic leukemia
In a nutshell This study aimed to investigate the outcomes for patients with newly diagnosed acute lymphoblastic leukemia who were treated liposomal vincristine and chemotherapy. This study concluded that this combination was safe and effective in these patients. Some background Liposomal vincristine (Marqibo) is a...
Read MoreBendamustine, ofatumumab and ibrutinib treatment for chronic lymphocytic leukemia with high tumor load
In a nutshell This study aimed to investigate if the bendamustine debunking (reducing tumor size) followed by ofatumumab and ibrutinib treatment was safe and effective in patients with chronic lymphocytic leukemia and a high tumor load. This study concluded that this treatment was safe and effective in...
Read MoreNCCN guidelines for children with acute lymphoblastic leukemia
In a nutshell These guidelines aimed to provide information on managing acute lymphoblastic leukemia in pediatric patients. Some background Acute lymphoblastic leukemia (ALL) is the most common cancer in pediatric patients. Advancements in technology have led to improved survival rates for these...
Read More
