In a nutshell The study evaluated treatment outcomes in patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) who continued blinatumomab (Blincyto; BL) after initial therapy. The authors found that long-term BL therapy can improve survival in these patients. Some background 45% of adults with ALL experience R/R...
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The link between treatment outcomes and quality of life in patients with chronic myeloid leukemia under tyrosine kinase inhibitor therapy
In a nutshell The study examined whether health-related quality of life (HRQoL) relates to the molecular response (MR) to tyrosine kinase inhibitors (TKIs) in patients with chronic-phase chronic myeloid leukemia (CP-CML). The authors found that improved MR had differential effects on HRQoL in such patients. Some background TKIs are a treatment used...
Read MoreTreatment recommendations for patients with acute myeloid leukemia.
In a nutshell This article provided treatment recommendations for patients with acute myeloid leukemia (AML). Some background The standard treatment for patients diagnosed with AML is a chemotherapy combination. Once there are no signs of AML (remission), patients are given post-remission chemotherapy to ensure it does not return. However,...
Read MoreLong-term effects of ofatumumab and chlorambucil in previously untreated patients with chronic lymphocytic leukemia
In a nutshell The study evaluated the long-term effectiveness and safety of Ofatumumab (Arzerra) and chlorambucil (Leukeran) (CHL) in patients with previously untreated chronic lymphocytic leukemia (CLL). The authors found that the combination therapy safely improved clinical outcomes in such patients in 5 years, compared to chlorambucil alone. Some...
Read MoreHemopoietic stem cell transplant after chimeric antigen receptor T-cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia
In a nutshell This study aimed to investigate if a hemopoietic stem cell transplant should be carried out after chimeric antigen receptor T cell therapy in patients with B-cell acute lymphoblastic leukemia. This study concluded that this treatment path led to high event-free survival in these patients. Some background...
Read MoreDo stem cell transplants improve patients’ long-term survival?
In a nutshell This study examined the long-term survival of patients who received stem cell transplants (SCT) and compared them to the general population. The authors found that patients who received SCTs had almost the same chance of survival as the general population and identified factors that alter this chance. Some background Treatments such as...
Read MoreDo stem cell transplants improve patients’ long-term survival?
In a nutshell This study examined the long-term survival of patients who received stem cell transplants (SCT) and compared them to the general population. The authors found that patients who received SCTs had almost the same chance of survival as the general population and identified factors that alter this chance. Some background Treatments such as...
Read MoreEvaluating the risk of late relapse in patients with acute lymphoblastic leukemia
In a nutshell This study aimed to investigate the occurrence and characteristics of late relapse in adult patients with acute lymphoblastic leukemia. This study concluded that late relapse in these patients is not uncommon and leads to better outcomes after relapse compared to early relapse. Some background Late relapse is the return...
Read MoreESMO guidelines for acute myeloid leukemia in adult patients
In a nutshell These updated guidelines aim to provide information on managing acute myeloid leukemia in adult patients. Some background The occurrence of acute myeloid leukemia (AML) depends on the age of patients. Case numbers tend to rise significantly in patients aged 60 and over. Therapies for AML in adult...
Read MoreThe effect of stomach acid suppressants on the safety and effectiveness of dasatinib in patients with chronic myeloid leukemia
In a nutshell This study aimed to investigate the influence of stomach acid suppressants on dasatinib treatment in patients with chronic-phase chronic myeloid leukemia. This study concluded that these drugs did not influence dasatinib treatment in this patient group. Some background...
Read MoreDoes the choice of anthracycline and transplant impact outcomes for patients with acute myeloid leukemia?
In a nutshell This study aimed to investigate the outcomes for patients with acute myeloid leukemia based on anthracycline and transplant type. This study concluded that the long-term outcomes for these patients were similar regardless of anthracycline and transplant choice. Some background...
Read MoreEvaluating imatinib treatment in children and adolescents with chronic myeloid leukemia
In a nutshell The study evaluated the effectiveness and safety of imatinib (Gleevec) in treating children and adolescents with chronic myeloid leukemia (CML). The main finding was that imatinib was effective against CML and safe in this patient population. Some background Imatinib deactivates a cancerous enzyme called BCR-ABL1. Lately, imatinib...
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