In a nutshell This study aimed to compare outcomes of allogeneic hematopoietic stem cell transplant (alloHSCT) using cryopreserved (frozen) and fresh grafts in patients with blood cancers who received post-transplant cyclophosphamide (Cytoxan). This study concluded that cryopreservation (CP) does not affect the outcomes of HSCT in these patients....
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In a nutshell This study aimed to investigate if acalabrutinib (Calquence) was safe and effective as a treatment for patients with relapsed or refractory chronic lymphocytic leukemia. This study concluded that acalabrutinib was safe and effective in these patients. Some background Acalabrutinib is commonly...
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In a nutshell This review aimed to discuss the toxicities of ibrutinib (Imbruvica) treatment and how to manage them. This review concluded that patients should be regularly monitored for toxicities and actively treated to reduce side effects and avoid disruption to treatment. Some background Ibrutinib is a...
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In a nutshell This study aimed to compare the effectiveness and safety of generic and branded imatinib in patients with newly diagnosed chronic-phase chronic myeloid leukemia. This study concluded that generic and branded imatinib had similar effectiveness and safety in these patients. Some...
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In a nutshell The study evaluated outcomes after stopping PEG–asparaginase (PEG-ANAse; Oncaspar) and substituting with Erwinia ASNase (Elspar) in children with B-cell acute lymphoblastic leukemia (B-ALL). The main finding was that completely stopping ASNase was associated with poorer outcomes in such patients. Some background...
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In a nutshell This study aimed to investigate the safety and effectiveness of different chemotherapy and targeted therapy combinations given as frontline treatment in patients with chronic lymphocytic leukemia in a real-world setting. This study concluded that some treatments have a real-world activity that is comparable to clinical trial...
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In a nutshell The study evaluated the occurrence of differentiation syndrome (DS) in patients with IDH-mutated acute myeloid leukemia (AML) under ivosidenib (Tibsovo) and enasidenib (Idhifa) therapy. The authors found that DS is a common and adverse condition in such patients. Some background Mutations or changes in the isocitrate dehydrogenase (IDH)...
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In a nutshell The report recommends how to manage patients with chronic-phase chronic myeloid leukemia (CP-CML) who failed to respond to 2nd generation tyrosine kinase inhibitors (TKIs). The authors suggested to consider patient-specific factors and personalize treatment for such patients. Some background TKIs deactivate cancerous enzymes which cause...
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In a nutshell This study aimed to investigate if arsenic trioxide was safe and effective as a maintenance treatment for patients with acute promyelocytic leukemia. This study concluded that this maintenance treatment was safe and effective in these patients. Some background Acute promyelocytic...
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In a nutshell This study aimed to investigate fine motor (movement) impairments in children with acute lymphoblastic leukemia who are receiving maintenance treatment. This study concluded that a high percentage of these patients experienced fine motor difficulties. Some background Treatments for...
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In a nutshell This study aimed to investigate the safety and effectiveness of zanubrutinib in patients with relapsed/unresponsive chronic lymphocytic leukemia. This study concluded that zanubrutinib was well tolerated and with promising effectiveness in these patients. Some background Bruton...
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In a nutshell The study evaluated occurrence, risk-factor, and exercise response of cardiac autonomic dysfunction (CAD) in adult survivors of childhood acute lymphoblastic leukemia (ALL). The authors found that over one-third of survivors developed CAD. It was related to lower exercise capacity. Some background Survivors of childhood ALL have reduced...
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