In a nutshell This study aimed to investigate treatment outcomes with transplant and tyrosine kinase inhibitors for childhood chronic myeloid leukemia. This study concluded that some tyrosine kinase inhibitors provide better outcomes for these patients. Some background Chronic myeloid leukemia (CML) is a rare disease in childhood....
Read More
In a nutshell This study aimed to investigate if venetoclax and intense chemotherapy is a safe and effective treatment in older patients with acute myeloid leukemia. This study concluded that this treatment was safe and effective in these patients. Some background Venetoclax (Venclexta) is a...
Read More
In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation. The authors found that sorafenib maintenance therapy decreased the risks of relapse and mortality after HSCT in such...
Read More
In a nutshell This study aimed to investigate the outcomes and side effects of ibrutinib in patients with chronic lymphocytic leukemia in the real-world setting. This study concluded that the outcomes for these patients in the real-world setting were similar to clinical trials but the rate of side...
Read More
In a nutshell This study aimed to investigate if donor type impacts on the overall outcomes of allogeneic stem cell transplant for children with very high-risk acute lymphoblastic leukemia. This study concluded that donor type does impact on these patients and that worse outcomes are seen with mismatched donors. Some...
Read More
In a nutshell This study aimed to investigate the impact of risk-stratified therapy on long-term toxicity in patients with childhood acute lymphoblastic leukemia. This study concluded that risk-stratified therapy has reduced late complications and mortality among survivors of standard-risk acute lymphoblastic leukemia. Some background...
Read More
In a nutshell This study aimed to investigate the role of antithymocyte globulin in preventing graft-versus-host disease after matched sibling donor transplantation. This study concluded that this treatment can reduce the occurrence of graft-versus-host-disease in these patients. Some background One...
Read More
In a nutshell This study aimed to investigate treatment-free remission in patients with chronic myeloid leukemia. This study concluded that some patients can experience late relapses and that long term follow-up is mandatory for these patients. Some background Treatment-free remission (TFR) can be used in patients with chronic myeloid...
Read More
In a nutshell This trial is comparing the effectiveness of a combined regimen of venetoclax (Venclexta) and obinutuzumab (Gazyva) or VEN-G to an existing drug regimen of fludarabine (Fludara), cyclophosphamide (Cytoxan), and rituximab (Rituxan) or FCR, or bendamustine (Treanda) and rituximab...
Read More
In a nutshell This study aimed to investigate the heart function of acute lymphoblastic leukemia survivors who had been treated with anthracyclines. This study concluded that these patients had decreased heart function long after treatment. Some background Anthracyclines are a type of chemotherapy drug. Examples are daunorubicin...
Read More
Recent research presented at a virtual meeting of the American Association for Cancer Research 1 indicates the need for greater care and continued social distancing for those who are in treatment for cancer and – in one study that was presented – those who have a recent history of cancer (the research looked at people from 2015 to the...
Read More
In a nutshell This study aimed to investigate the outcomes of imatinib treatment for pediatric patients with chronic-phase chronic myeloid leukemia. This study concluded that imatinib should remain the frontline treatment of choice for these patients. Some background Chronic myeloid leukemia (CML) is...
Read More
