In a nutshell This study aimed to compare the effectiveness of ibrutinib (Imbruvica) to idelalisib (Zydelig)–rituximab (Rituxan) combination for patients with chronic lymphocytic leukemia in a real-life setting. This study concluded that ibrutinib appears to improve survival...
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In a nutshell This study aimed to investigate if chemotherapy (CT) conditioning could replace total body irradiation (TBI) before stem cell transplant (SCT) in children with acute lymphoblastic leukemia (ALL). This study concluded that TBI in combination with CT was safer and more effective than CT conditioning alone in these...
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In a nutshell This study investigated the effectiveness of azacitidine (Onureg) tablets as maintenance therapy in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy. The data showed that azacitidine tablets improved the survival of these patients. Some background Acute myelogenous leukemia (AML) is a...
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In a nutshell This study aimed to investigate the combination of dasatinib (Sprycel) and blinatumomab (Blincyto) as a first-line therapy in patients with Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL). This study concluded that this treatment combination led to better response and survival in these...
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In a nutshell This study aimed to investigate the effect of chemotherapy dose intensity on outcomes for patients with adult T-cell leukemia/lymphoma. This study concluded that higher chemotherapy dose intensity improves outcomes for these patients. Some background Adult T-cell leukemia/lymphoma (ATL) is an aggressive blood cancer. It...
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In a nutshell This study aimed to investigate allogeneic blood or marrow transplantation (alloBMT) with post-transplant cyclophosphamide (PTCy; Cytoxan) in patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). This study concluded that patients alloBMT with PTCy in first complete remission (CR1) leads...
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In a nutshell This study aimed to investigate the safety and effectiveness of venetoclax (Venclexta) combined with low dose cytarabine (LDAC; Cytosar-U) in patients with acute myeloid leukemia (AML) who cannot undergo intensive chemotherapy. This study concluded that this combination is a promising treatment for...
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In a nutshell This study aimed to investigate the effectiveness of inotuzumab ozogamicin (InO; Besponsa) in patients with Philadelphia chromosome-positive (Ph+) relapsed/refractory (r/r) acute lymphoblastic leukemia (ALL). This study concluded that this treatment is a good option for these patients. Some background Ph chromosome...
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In a nutshell This study aimed to investigate if the combination of recombinant human granulocyte colony-stimulating factor (rhG-CSF; Filgrastim) and decitabine (Dacogen) would be effective in preventing relapse after transplant for patients with high-risk (HR) acute myeloid leukemia (AML). This study...
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In a nutshell This study aimed to investigate the safety and effectiveness of tisagenlecleucel (TL; Kymriah) in a real-world setting as a treatment for acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). This study concluded that TL has similar effectiveness and improved safety in a real-world...
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In a nutshell This study aimed to investigate the safety and effectiveness of the combination of ivosidenib (Tibsovo) and azacitidine (Vidaza) in patients with acute myeloid leukemia (AML) with isocitrate dehydrogenase 1 (IDH1) mutation (permanent change). This study concluded that this combination was well tolerated and...
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In a nutshell This study aimed to compare the effectiveness of acalabrutinib (Calquence) alone and in combination with obinutuzumab (Gazyva) to standard treatments for patients with chronic lymphocytic leukemia (CLL). This study concluded that acalabrutinib showed high effectiveness...
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