In a nutshell This phase 3 trial will investigate a new drug FE 999049 for the treatment of infertility. The main outcome will be the ongoing pregnancy rate. The details There are several steps in the treatment of infertility. The first step involves harvesting eggs or oocytes. Once oocytes are harvested, in vitro fertilization (IVF) or...
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In a nutshell This study investigated if the interpregnancy interval (IPI; the time between pregnancies) has an effect on the following pregnancy. They found that an IPI of less than 12 months or greater than 60 months is associated with worse pregnancy outcomes. Some background The interpregnancy interval (IPI) is the time between the end of one...
Read MoreIn a nutshell This study investigated the use of progestogen (PTG) to prevent miscarriage in women with recurrent miscarriages (RM). They found that PTG reduces the chance of miscarriage in following pregnancies. Some background Pregnancy loss or miscarriage affects many women. Some women may experience several miscarriages, or recurrent miscarriages...
Read MoreIn a nutshell This study investigated if letrozole (Femara) improves fertility outcomes in patients with polycystic ovary syndrome. They found that letrozole was not superior to clomiphene (Clomid) in treating infertility in these women. Some background Polycystic ovary syndrome (PCOS) is a condition that can lead to infertility. It is...
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In a nutshell This study reviewed the use of vaccinations for women seeking fertility. Some background Vaccinations are used to prevent developing certain diseases. In some cases, a woman seeking fertility treatment may not be vaccinated. Complications may arise if a woman is not fully vaccinated. There may be risks to both the mother and...
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In a nutshell This study investigated if a technology that detects chromosomal abnormalities (PGT-A) can improve in vitro fertilization (IVF) success. They found that this technology reduced the risk of failed embryo transfer and clinical miscarriage. Some background In vitro fertilization (IVF) is an assisted reproductive technology (ART). Eggs...
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In a nutshell This study investigated factors affecting monozygotic twins (MZT) rates in patients undergoing fertility treatment. They found that embryo stage at transfer and higher embryos numbers increased the risk of MZT. Some background Monozygotic is the term used to describe identical twins. Monozygotic twins (MZT) occur when two embryos form...
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In a nutshell This study reviewed dietary factors that may influence male fertility. Some background Male infertility is an increasing problem. In many cases, there is no obvious cause for male infertility. Some studies suggest that diet may play a role in this. Men that are overweight or obese are more likely to be infertile. The importance of a...
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In a nutshell This study reviewed the link between smoking and reduced fertility. Some background Smoking is not recommended for pregnant women. It is linked to a number of pregnancy complications. These include miscarriage, low birth weight, and premature labor. The effect of smoking on male and female fertility is less well understood. The American...
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In a nutshell This study investigated if a mixed herbal extract of Trigonella foenum–graecum and Lespedeza cuneata (TFGL) could improve testosterone deficiency. They found that TFGL improved testosterone levels in men with testosterone deficiency. Some background Testosterone is a male sex hormone. It has a number of functions in the body....
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In a nutshell This study investigated if progestin-primed ovarian stimulation (PPOS) is associated with infant birth defects. They found that PPOS is not associated with negative outcomes in infants. Some background Assisted reproductive techniques (ART) include in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). In order to...
Read MoreIn a nutshell This study investigated if caffeine intake affects the success of fertility treatment. They found that the outcome of fertility treatment was not associated with caffeine intake. Some background Caffeine is found in popular food and drinks such as coffee and chocolate. Caffeine causes you to feel alert and energized. It is unclear...
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